AG1024
CAS No. 65678-07-1
AG1024 ( AG1024; AG-1024; AG 1024. Tyrphostin )
Catalog No. M18961 CAS No. 65678-07-1
AG-1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 47 | In Stock |
|
10MG | 79 | In Stock |
|
25MG | 147 | In Stock |
|
50MG | 259 | In Stock |
|
100MG | 441 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
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Biological Information
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Product NameAG1024
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NoteResearch use only, not for human use.
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Brief DescriptionAG-1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).
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DescriptionAG-1024 is also called Tyrphostin, is a selective inhibitor of IGF-1R. AG-1024 was used to evaluate effects on proliferation, radiosensitivity, and radiation-induced cell apoptosis in a human breast cancer cell line MCF-7. Exposure to Tyrphostin AG 1024 inhibited proliferation and induced apoptosis in a time-dependent manner, and the degree of growth inhibition for IC20 plus irradiation (4 Gy) was up to 50% compared to the control. Tyrphostin AG 1024 could be used as a potential therapeutic agent in combination with irradiation.
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SynonymsAG1024; AG-1024; AG 1024. Tyrphostin
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PathwayOthers
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TargetOther Targets
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RecptorIGF-1R; Insulin Receptor
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number65678-07-1
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Formula Weight305.17
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Molecular FormulaC14H13BrN2O
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Purity98%
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SolubilityDMSO : ≥ 50 mg/mL; 163.84 mM
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SMILESCC(C)(C)c1c(c(cc(c1)C=C(C#N)C#N)Br)O
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Chemical Name2-(3-bromo-5-tert-butyl-4-hydroxybenzylidene)malononitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. von Willebrand M, et al. Y Res, 2003, 63(6), 1420-1429.
molnova catalog
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