AG1024

Research use only, not for human use.

AG-1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).

AG-1024 is also called Tyrphostin, is a selective inhibitor of IGF-1R. AG-1024 was used to evaluate effects on proliferation, radiosensitivity, and radiation-induced cell apoptosis in a human breast cancer cell line MCF-7. Exposure to Tyrphostin AG 1024 inhibited proliferation and induced apoptosis in a time-dependent manner, and the degree of growth inhibition for IC20 plus irradiation (4 Gy) was up to 50% compared to the control. Tyrphostin AG 1024 could be used as a potential therapeutic agent in combination with irradiation.

AG1024; AG-1024; AG 1024. Tyrphostin

Others

Other Targets

IGF-1R; Insulin Receptor

Cancer

——

65678-07-1

305.17

C14H13BrN2O

98%

DMSO : ≥ 50 mg/mL; 163.84 mM

CC(C)(C)c1c(c(cc(c1)C=C(C#N)C#N)Br)O

2-(3-bromo-5-tert-butyl-4-hydroxybenzylidene)malononitrile

(-20℃)

With Ice Pack

≥ 2 years