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AFN-1252
CAS No. 620175-39-5
AFN-1252( API-1252 | Debio-1452 )
Catalog No. M15347 CAS No. 620175-39-5
A potent inhibitor of bacterial enoyl-ACP reductase FabI.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 53 | In Stock |
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| 5MG | 87 | In Stock |
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| 10MG | 140 | In Stock |
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| 25MG | 260 | In Stock |
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| 50MG | 399 | In Stock |
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| 100MG | 588 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAFN-1252
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NoteResearch use only, not for human use.
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Brief DescriptionA potent inhibitor of bacterial enoyl-ACP reductase FabI.
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DescriptionA potent inhibitor of bacterial enoyl-ACP reductase FabI; demonstrates MICs of 0.015 and 0.008 ug/ml for S. aureus ATCC 29213 and S. aureus ATCC 33592 (MRSA), respectively; demonstrates a Staphylococcus-specific spectrum of activity.Bacterial Infection Phase 2 Clinical.
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In Vitro——
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In VivoAnimal Model:Female 5- to 6-week-old CD-1 mice (18 to 22 g) with S. aureus Smith bacterial inoculumDosage:0.03, 0.1, 0.3, 1, 3 mg/kg Administration:Oral gavage; single dose Result:Was efficacious in a mouse model of septicemia, with 100% survival obtained with a single oral dose of 1 mg/kg. The calculated ED50s (95% confidence limits) were 0.15 (0.11 to 0.21) mg/kg.
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SynonymsAPI-1252 | Debio-1452
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PathwayGPCR/G Protein
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TargetAntibacterial
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Recptorenoyl-acylcarrierproteinreductase(FabI)
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Research AreaInfection
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IndicationBacterial Infection
Chemical Information
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CAS Number620175-39-5
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Formula Weight375.4204
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Molecular FormulaC22H21N3O3
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Purity>98% (HPLC)
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SolubilityDMSO: 5.8 mg/mL (Need ultrasonic)
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SMILESO=C(N(C)CC1=C(C)C2=CC=CC=C2O1)/C=C/C3=CC(CC4)=C(N=C3)NC4=O
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Chemical Name2-Propenamide, N-methyl-N-[(3-methyl-2-benzofuranyl)methyl]-3-(5,6,7,8-tetrahydro-7-oxo-1,8-naphthyridin-3-yl)-, (2E)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Karlowsky JA, et al. Antimicrob Agents Chemother. 2007 Apr;51(4):1580-1.
2. Karlowsky JA, et al. Antimicrob Agents Chemother. 2009 Aug;53(8):3544-8.
3. Parsons JB, et al. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15378-83.
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