Cart
sales@molnova.com
Home - Products - GPCR/G Protein - Antibacterial - AFN-1252

AFN-1252

CAS No. 620175-39-5

AFN-1252 ( API-1252;Debio-1452 )

Catalog No. M15347 CAS No. 620175-39-5

A potent inhibitor of bacterial enoyl-ACP reductase FabI.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 53 In Stock
5MG 87 In Stock
10MG 140 In Stock
25MG 260 In Stock
50MG 399 In Stock
100MG 588 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    AFN-1252
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent inhibitor of bacterial enoyl-ACP reductase FabI.
  • Description
    A potent inhibitor of bacterial enoyl-ACP reductase FabI; demonstrates MICs of 0.015 and 0.008 ug/ml for S. aureus ATCC 29213 and S. aureus ATCC 33592 (MRSA), respectively; demonstrates a Staphylococcus-specific spectrum of activity.Bacterial Infection Phase 2 Clinical
  • Synonyms
    API-1252;Debio-1452
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    enoyl-acylcarrierproteinreductase(FabI)
  • Research Area
    Infection
  • Indication
    Bacterial Infection

Chemical Information

  • CAS Number
    620175-39-5
  • Formula Weight
    375.42
  • Molecular Formula
    C22H21N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 5.8 mg/mL (Need ultrasonic)
  • SMILES
    O=C(N(C)CC1=C(C)C2=CC=CC=C2O1)/C=C/C3=CC(CC4)=C(N=C3)NC4=O
  • Chemical Name
    2-Propenamide, N-methyl-N-[(3-methyl-2-benzofuranyl)methyl]-3-(5,6,7,8-tetrahydro-7-oxo-1,8-naphthyridin-3-yl)-, (2E)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Karlowsky JA, et al. Antimicrob Agents Chemother. 2007 Apr;51(4):1580-1.
2. Karlowsky JA, et al. Antimicrob Agents Chemother. 2009 Aug;53(8):3544-8.
3. Parsons JB, et al. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15378-83.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Ombuoside

    Ombuoside has antifungal activity. Ombuoside shows significant antioxidant activity in the DPPH, and TEAC, reducing power assays.Ombuoside is a glycoside ombuoside isolated from Gynostemma pentaphyllum.

  • Caerulomycin A

    Caerulomycin A (Cerulomycin; Caerulomycin) is an antifungal compound. Which induces generation of T cells, enhances TGF-β-Smad3 protein signaling via suppressing interferon-γ-induced STAT1 signaling.

  • BM-635

    BM-635 is a small molecule anti-mycobacterial compound acting by inhibiting the mycobacterial membrane protein Large 3 (MmpL3).

Sign In Join Free