AEE-788

CAS No. 497839-62-0

AEE-788 ( AEE 788;AEE788;NVP-AEE 788 )

Catalog No. M14666 CAS No. 497839-62-0

A potent, orally bioavailable dual EGFR/VEGFR receptor tyrosine kinase inhibitor with IC50 of 2, 6, 77 and 59 nM for EGFR, ErbB2, KDR and Flt-1, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 35 In Stock
5MG 58 In Stock
10MG 95 In Stock
25MG 178 In Stock
50MG 309 In Stock
100MG 464 In Stock
500MG 1044 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    AEE-788
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, orally bioavailable dual EGFR/VEGFR receptor tyrosine kinase inhibitor with IC50 of 2, 6, 77 and 59 nM for EGFR, ErbB2, KDR and Flt-1, respectively.
  • Description
    A potent, orally bioavailable dual EGFR/VEGFR receptor tyrosine kinase inhibitor with IC50 of 2, 6, 77 and 59 nM for EGFR, ErbB2, KDR and Flt-1, respectively; inhibits growth factor-induced EGFR and ErbB2 phosphorylation in cells with IC50 of 11 and 220 nM, respectively, demonstrates antiproliferative activity against a range of EGFR and ErbB2-overexpressing cell lines; shows antitumor and antiangiogenic activity in vivo.Brain Cancer Phase 2 Discontinued
  • Synonyms
    AEE 788;AEE788;NVP-AEE 788
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    c-Abl;c-Fms;EGFR;FLT1;HER2/ErbB2
  • Research Area
    Cancer
  • Indication
    Brain Cancer

Chemical Information

  • CAS Number
    497839-62-0
  • Formula Weight
    440.58
  • Molecular Formula
    C27H32N6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10 mM
  • SMILES
    C[C@@H](NC1=C2C(NC(C3=CC=C(CN4CCN(CC)CC4)C=C3)=C2)=NC=N1)C5=CC=CC=C5
  • Chemical Name
    7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 6-[4-[(4-ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Traxler P, et al. Cancer Res. 2004 Jul 15;64(14):4931-41.
2. Goudar RK, et al. Mol Cancer Ther. 2005 Jan;4(1):101-12.
3. Park YW, et al. Clin Cancer Res. 2005 Mar 1;11(5):1963-73.
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