ACY-738

Research use only, not for human use.

ACY-738 (ACY738) is a potent and specific HDAC6 inhibitor (IC50=1.7 nM) with improved brain bioavailability; displays 60-1500 fold selectivity over class I HDACs.

ACY-738 (ACY738) is a potent and specific HDAC6 inhibitor (IC50=1.7 nM) with improved brain bioavailability; displays 60-1500 fold selectivity over class I HDACs; induces dramatic increase in α-tubulin acetylation in brain and stimulates mouse exploratory behaviors; increases the innervation of the neuromuscular junctions in the gastrocnemius muscle and improves the motor and sensory nerve conduction in the mutant HSPB1-induced CMT2 mouse model.Depression Preclinical

ACY738;ACY 738

Cell Cycle/DNA Damage

HDAC

HDAC6

Neurological Disease

Depression

1375465-91-0

270.29

C14H14N4O2

>98% (HPLC)

DMSO: ≥ 32 mg/mL

O=C(C1=CN=C(NC2(C3=CC=CC=C3)CC2)N=C1)NO

5-Pyrimidinecarboxamide, N-hydroxy-2-[(1-phenylcyclopropyl)amino]-

(-20℃)

With Ice Pack

≥ 2 years