Cart
sales@molnova.com
Home - Products - Immunology/Inflammation - Hydroxylase - ACT-678689

ACT-678689

CAS No. 1783256-96-1

ACT-678689( Compound Example 1.53.4 )

Catalog No. M23798 CAS No. 1783256-96-1

ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 293 In Stock
10MG 451 In Stock
25MG 735 In Stock
50MG 1017 In Stock
100MG 1377 In Stock
500MG 2673 In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    ACT-678689
  • Note
    Research use only, not for human use.
  • Brief Description
    ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM.
  • Description
    ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM.
  • In Vitro
    TPH comprises two isoforms: TPH2 is mainly expressed in neuronal cell types in the central nervous system (CNS), while TPH1 is mainly expressed in peripheral tissues, including the entrochromaffin cells (EC) in the gut, where it is responsible for synthesizing 5HT that is stored in circulating blood platelets.
  • In Vivo
    ——
  • Synonyms
    Compound Example 1.53.4
  • Pathway
    Immunology/Inflammation
  • Target
    Hydroxylase
  • Recptor
    Tryptophan hydroxylase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1783256-96-1
  • Formula Weight
    565.04
  • Molecular Formula
    C23H22ClFN6O4S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:120 mg/mL (212.37 mM; Need ultrasonic)
  • SMILES
    Cc(s1)nn2c1nc(CC1)c2[C@H](c(ccc(C)c2)c2F)N1C(COc1ccc(NS(C)(=O)=O)nc1Cl)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Daniel Bur, et al. Tricyclic piperidine compounds. WO2015075023A1.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Sapropterin Hydrochl...

    Sapropterin dihydrochloride is phenylalanine hydroxylase agonist that is approved for the treatment of BH4 responsive PKU.

  • Bupicomide

    Bupicomide is a dopamine beta hydroxylase inhibitor with antihypertensive and vasodilatory activity that reduces 14C-norepinephrine biosynthesis of 14C-dopamine and can be used to study hypertension.

  • ACT-678689

    ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM.

Sign In Join Free