ACT-389949

CAS No. 1258417-54-7

ACT-389949 ( —— )

Catalog No. M23429 CAS No. 1258417-54-7

ACT-389949 is a potent and selective agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 311 In Stock
10MG 441 In Stock
25MG 707 In Stock
50MG 981 In Stock
100MG 1332 In Stock
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Biological Information

  • Product Name
    ACT-389949
  • Note
    Research use only, not for human use.
  • Brief Description
    ACT-389949 is a potent and selective agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes.
  • Description
    ACT-389949 is a potent and selective agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. It has the potential for the treatment of inflammatory disorders.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    FPR2/ALX
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1258417-54-7
  • Formula Weight
    428.4
  • Molecular Formula
    C20H18F2N6O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mg/mL (23.34 mM; ultrasonic and adjust pH to 1 with HCl)
  • SMILES
    O=C(NC1=NN(N=C1)CC2=NC(C(F)(C)F)=CO2)C3=C(OC(C)=N3)C4=CC=CC(C)=C4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Stalder AK,et al. Biomarker-guided clinical development of the first-in-class anti-inflammatory FPR2/ALX agonist ACT-389949. Br J Clin Pharmacol. 2017 Mar;83(3):476-486.
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