ACT-389949 ( —— )

Catalog No. M23429 CAS No. 1258417-54-7

ACT-389949 is a potent and selective agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

ACT-389949
Note

Research use only, not for human use.
Brief Description

ACT-389949 is a potent and selective agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes.
Description

ACT-389949 is a potent and selective agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. It has the potential for the treatment of inflammatory disorders.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

FPR2/ALX
Research Area

——
Indication

——

Chemical Information

CAS Number

1258417-54-7
Formula Weight

428.4
Molecular Formula

C20H18F2N6O3
Purity

>98% (HPLC)
Solubility

DMSO:10 mg/mL (23.34 mM; ultrasonic and adjust pH to 1 with HCl)
SMILES

O=C(NC1=NN(N=C1)CC2=NC(C(F)(C)F)=CO2)C3=C(OC(C)=N3)C4=CC=CC(C)=C4
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Stalder AK,et al. Biomarker-guided clinical development of the first-in-class anti-inflammatory FPR2/ALX agonist ACT-389949. Br J Clin Pharmacol. 2017 Mar;83(3):476-486.

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