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ABT-751

CAS No. 141430-65-1

ABT-751( ABT751 | ABT 751 | E7010 | E-7010 | E 7010 )

Catalog No. M11717 CAS No. 141430-65-1

ABT-751 (E-7010) is an orally active antimitotic agent that inhibits tubulin polymerization.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ABT-751
  • Note
    Research use only, not for human use.
  • Brief Description
    ABT-751 (E-7010) is an orally active antimitotic agent that inhibits tubulin polymerization.
  • Description
    ABT-751 (E-7010) is an orally active antimitotic agent that inhibits tubulin polymerization, exhibits consistent growth-inhibitory activities against a panel of human tumor cell lines (IC50=0.06-0.8 ug/mL); shows good antitumor activity against various rodent tumors and human tumor xenografts, Lung Cancer Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ABT751 | ABT 751 | E7010 | E-7010 | E 7010
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Microtubule/Tubulin
  • Recptor
    microtubule
  • Research Area
    Cancer
  • Indication
    Lung Cancer

Chemical Information

  • CAS Number
    141430-65-1
  • Formula Weight
    371.4
  • Molecular Formula
    C18H17N3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 48 mg/mL
  • SMILES
    COC1=CC=C(C=C1)S(=O)(=O)NC1=C(NC2=CC=C(O)C=C2)N=CC=C1
  • Chemical Name
    Benzenesulfonamide, N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxy-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Koyanagi N, et al. Cancer Res. 1994 Apr 1;54(7):1702-6. 2. Yoshimatsu K, et al. Cancer Res. 1997 Aug 1;57(15):3208-13. 3. Segreti JA, et al. Cancer Chemother Pharmacol. 2004 Sep;54(3):273-81. 4. Yoshimatsu K, et al. Cancer Res. 1997 Aug 1;57(15):3208-13.
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