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ABT-080
CAS No. 189498-57-5
ABT-080( VML-530 | ABT080 )
Catalog No. M12975 CAS No. 189498-57-5
ABT-080 is a potent FLAP inhibitor that inhibits ionophore-stimulated LTB(4) formation with with IC50 of 20 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 45 | Get Quote |
|
| 10MG | 68 | Get Quote |
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| 25MG | 115 | Get Quote |
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| 50MG | 173 | Get Quote |
|
| 100MG | 258 | Get Quote |
|
| 200MG | 388 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameABT-080
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NoteResearch use only, not for human use.
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Brief DescriptionABT-080 is a potent FLAP inhibitor that inhibits ionophore-stimulated LTB(4) formation with with IC50 of 20 nM.
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DescriptionABT-080 is a potent FLAP inhibitor that inhibits ionophore-stimulated LTB(4) formation with with IC50 of 20 nM; selectively inhibits zymosan-stimulated mouse peritoneal macrophages producing LTC(4) with IC50 of 0.16 nM, 9000-fold selectivity over PGE(2) producing; demonstrates leukotriene inhibition with oral dosing in a rat pleural inflammation model.Asthma Discontinued.
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In Vitro——
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In Vivo——
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SynonymsVML-530 | ABT080
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PathwayImmunology/Inflammation
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TargetFLAP
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RecptorFLAP
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Research AreaInflammation/Immunology
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IndicationAsthma
Chemical Information
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CAS Number189498-57-5
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Formula Weight590.655
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Molecular FormulaC37H31N2NaO4
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name4,4-Bis(4-(2-quinolylmethoxy)phenyl)pentanoic acid sodium salt
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kolasa T, et al. J Med Chem. 2000 Aug 24;43(17):3322-34.
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