AB-680 ( —— )

Catalog No. M23955 CAS No. 2105904-82-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

AB-680
Note

Research use only, not for human use.
Brief Description

AB-680 is a highly potent, reversible, and selective inhibitor of CD73 (an ectonucleotidase, Ki: 4.9 pM for hCD73) with anti-tumor activity.
Description

AB-680 is a highly potent, reversible, and selective inhibitor of CD73 (an ectonucleotidase, Ki: 4.9 pM for hCD73) with anti-tumor activity, displays >10,000-fold selectivity over related ectonucleotidases CD39.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

CD73
Research Area

——
Indication

——

CAS Number

2105904-82-1
Formula Weight

580.8
Molecular Formula

C20H24ClFN4O9P2
Purity

>98% (HPLC)
Solubility

DMSO:180 mg/mL (309.91 mM; Need ultrasonic)
SMILES

C[C@@H](c(cccc1)c1F)Nc1cc(Cl)nc2c1cnn2[C@@H]([C@@H]1O)O[C@H](COP(CP(O)(O)=O)(O)=O)[C@H]1O
Chemical Name

——

1.Lawson KV, et al. Discovery and Characterization of AB680, a Potent and Selective Small-Molecule CD73 Inhibitor for Cancer Immunotherapy.

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