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AAPK-25
CAS No. 2247919-28-2
AAPK-25 ( —— )
Catalog No. M26043 CAS No. 2247919-28-2
AAPK-25, a potent and selective dual inhibitor of Aurora/PLK, causes mitotic delay and cell arrest in prometaphase, via phosphorylation of the biomarker histone H3Ser10, followed by a surge in apoptosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 235 | Get Quote |
|
| 10MG | 348 | Get Quote |
|
| 25MG | 584 | Get Quote |
|
| 50MG | 831 | Get Quote |
|
| 100MG | 1134 | Get Quote |
|
| 500MG | 2268 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameAAPK-25
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NoteResearch use only, not for human use.
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Brief DescriptionAAPK-25, a potent and selective dual inhibitor of Aurora/PLK, causes mitotic delay and cell arrest in prometaphase, via phosphorylation of the biomarker histone H3Ser10, followed by a surge in apoptosis.
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DescriptionAAPK-25, a potent and selective dual inhibitor of Aurora/PLK, causes mitotic delay and cell arrest in prometaphase, via phosphorylation of the biomarker histone H3Ser10, followed by a surge in apoptosis. AAPK-25 targets Aurora A, Aurora B, and Aurora C with Kd values ??ranging from 23-289 nM, and PLK1, PLK2, and PLK3 with Kd values ??ranging from 55-456 nM. AAPK-25 has antitumor activity.(In Vitro):AAPK-25 inhibited HCT-116, Calu6, A549, and MCF-7 cells growth (IC50s: 0.4, 5.3, 11.6, and 2.3 μM). AAPK-25 dose-dependently induced apoptosis in HCT-116 cell line.(In Vivo):In the BALB/c nude mice tumor xenograft model, AAPK-25 enhanced the survival rate.
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number2247919-28-2
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Formula Weight442.3
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Molecular FormulaC21H13Cl2N3O2S
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Purity>98% (HPLC)
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Solubility——
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SMILESClc1ccc(cc1Cl)C(=O)Nc1ccc2cc(ccc2c1)C(=O)Nc1nccs1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Pacold ME, et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate [published correction appears in Nat Chem Biol. 2016 Jul 19;12 (8):656]. Nat Chem Biol. 2016;12(6):452-458.
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