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A66
CAS No. 1166227-08-2
A66 ( A 66; A-66 )
Catalog No. M10568 CAS No. 1166227-08-2
A66 (p110α inhibitor A66) is a potent, highly specific p110α inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 42 | In Stock |
|
| 5MG | 69 | In Stock |
|
| 10MG | 114 | In Stock |
|
| 25MG | 221 | In Stock |
|
| 50MG | 389 | In Stock |
|
| 100MG | 575 | In Stock |
|
| 500MG | 1197 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameA66
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NoteResearch use only, not for human use.
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Brief DescriptionA66 (p110α inhibitor A66) is a potent, highly specific p110α inhibitor.
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DescriptionA66 (p110α inhibitor A66) is a potent, highly specific p110α inhibitor with IC50 of 32, 30 and 43 nM for wt p110α, p110α E545K and p110α H1047R, respectively; displays little to no activity against p110β/γ/δ (IC50>3,000 nM), as well as class-III PI3Ks, mTOR, DNA-PK, and PI4Kα/β; induces reduction in focus formation CEF by the highly transforming iSH2 mutants KS459delN, DKRMNS560del, and K379E, blocks PI3K signalling and tumour growth in certain cell types.
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SynonymsA 66; A-66
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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Recptorp110α;p110γ;p110δ;PI3Kβ
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1166227-08-2
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Formula Weight393.52
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Molecular FormulaC17H23N5O2S2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(N1[C@H](C(N)=O)CCC1)NC2=NC(C)=C(C3=CSC(C(C)(C)C)=N3)S2
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Chemical Name1,2-Pyrrolidinedicarboxamide, N1-[2-(1,1-dimethylethyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-, (2S)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jamieson S, et al. Biochem J. 2011 Aug 15;438(1):53-62.
2. Sun M, et al. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15547-52.
3. Weigelt B, et al. Clin Cancer Res. 2013 Jul 1;19(13):3533-44.
2. Sun M, et al. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15547-52.
3. Weigelt B, et al. Clin Cancer Res. 2013 Jul 1;19(13):3533-44.
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