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A66

CAS No. 1166227-08-2

A66 ( A 66; A-66 )

Catalog No. M10568 CAS No. 1166227-08-2

A66 (p110α inhibitor A66) is a potent, highly specific p110α inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    A66
  • Note
    Research use only, not for human use.
  • Brief Description
    A66 (p110α inhibitor A66) is a potent, highly specific p110α inhibitor.
  • Description
    A66 (p110α inhibitor A66) is a potent, highly specific p110α inhibitor with IC50 of 32, 30 and 43 nM for wt p110α, p110α E545K and p110α H1047R, respectively; displays little to no activity against p110β/γ/δ (IC50>3,000 nM), as well as class-III PI3Ks, mTOR, DNA-PK, and PI4Kα/β; induces reduction in focus formation CEF by the highly transforming iSH2 mutants KS459delN, DKRMNS560del, and K379E, blocks PI3K signalling and tumour growth in certain cell types.
  • Synonyms
    A 66; A-66
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PI3K
  • Recptor
    p110α;p110γ;p110δ;PI3Kβ
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1166227-08-2
  • Formula Weight
    393.52
  • Molecular Formula
    C17H23N5O2S2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(N1[C@H](C(N)=O)CCC1)NC2=NC(C)=C(C3=CSC(C(C)(C)C)=N3)S2
  • Chemical Name
    1,2-Pyrrolidinedicarboxamide, N1-[2-(1,1-dimethylethyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-, (2S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jamieson S, et al. Biochem J. 2011 Aug 15;438(1):53-62.
2. Sun M, et al. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15547-52.
3. Weigelt B, et al. Clin Cancer Res. 2013 Jul 1;19(13):3533-44.
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