Cart
sales@molnova.com
A-967079
CAS No. 1170613-55-4
A-967079( A967079 | A 967079 )
Catalog No. M10572 CAS No. 1170613-55-4
A potent, selective TRPA1 channel blocker with IC50 of 51 nM and 101 nM for hTRPA1 and rTRPA1, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 45 | In Stock |
|
| 10MG | 61 | In Stock |
|
| 25MG | 135 | In Stock |
|
| 50MG | 237 | In Stock |
|
| 100MG | 405 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameA-967079
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective TRPA1 channel blocker with IC50 of 51 nM and 101 nM for hTRPA1 and rTRPA1, respectively.
-
DescriptionA potent, selective TRPA1 channel blocker with IC50 of 51 nM and 101 nM for hTRPA1 and rTRPA1, respectively; displays >1,000-fold selective over other TRP channels, and is >150-fold selective over 75 other ion channels, enzymes, and G-protein-coupled receptors; exhibits analgesic efficacy in allyl isothiocyanate-induced nocifensive response and osteoarthritic pain in rats (ED50=23.2 mg/kg), attenuates cold allodynia produced by nerve injury but does not alter noxious cold sensation in naive animals; orally bioavailable.Pain Preclinical
-
In Vitro——
-
In Vivo——
-
SynonymsA967079 | A 967079
-
PathwayMembrane Transporter/Ion Channel
-
TargetTRP/TRPV Channel
-
RecptorTRP/TRPV Channel
-
Research AreaNeurological Disease
-
IndicationPain
Chemical Information
-
CAS Number1170613-55-4
-
Formula Weight207.24
-
Molecular FormulaC12H14FNO
-
Purity>98% (HPLC)
-
SolubilityDMS : 100 mg/mL482.53 mM;H2O : < 0.1 mg/mL
-
SMILESCCC(/C(C)=C/C1=CC=C(F)C=C1)=N\O
-
Chemical Name(1E,3E)-1-(4-fluorophenyl)-2-methylpent-1-en-3-one oxime
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Chen J, et al. Pain. 2011 May;152(5):1165-72.
2. McGaraughty S, et al. Mol Pain. 2010 Mar 5;6:14.
3. Trevisan G, et al. Brain. 2016 May;139(Pt 5):1361-77.
molnova catalog
related products
-
PF-05105679
PF-05105679 is a potent, selective TRPM8 channel inhibitor with IC50 of 103 nM (human TRPM8 currents inhibition).
-
Pyr6
Pyr6 is a selective TRPC3 inhibitor with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).Pyr6 is an inhibitor of Ca2+ entry, which displays higher potency to inhibit Ca2+ entry mediated by CRAC channel than by TRPC3.Pyr3 is selective inhibitor of TRPC3, inhibited Orai1- and TRPC3-mediated Ca(2+) entry and currents as well as mast cell activation with similar potency.?
-
Clemizole
An H1 histamine receptor antagonist that substantially inhibits HCV replication by suppression of NS4B's RNA binding (IC50=24 nM) with little toxicity for the host cells.
