A-967079

Research use only, not for human use.

A potent, selective TRPA1 channel blocker with IC50 of 51 nM and 101 nM for hTRPA1 and rTRPA1, respectively.

A potent, selective TRPA1 channel blocker with IC50 of 51 nM and 101 nM for hTRPA1 and rTRPA1, respectively; displays >1,000-fold selective over other TRP channels, and is >150-fold selective over 75 other ion channels, enzymes, and G-protein-coupled receptors; exhibits analgesic efficacy in allyl isothiocyanate-induced nocifensive response and osteoarthritic pain in rats (ED50=23.2 mg/kg), attenuates cold allodynia produced by nerve injury but does not alter noxious cold sensation in naive animals; orally bioavailable.Pain Preclinical

A967079;A 967079

Membrane Transporter/Ion Channel

TRP/TRPV Channel

TRP/TRPV Channel

Neurological Disease

Pain

1170613-55-4

207.24

C12H14FNO

>98% (HPLC)

DMS : 100 mg/mL482.53 mM;H2O : < 0.1 mg/mL

CCC(/C(C)=C/C1=CC=C(F)C=C1)=N\O

(1E,3E)-1-(4-fluorophenyl)-2-methylpent-1-en-3-one oxime

(-20℃)

With Ice Pack

≥ 2 years