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A-893
CAS No. 1868232-32-9
A-893 ( A 893;A893 )
Catalog No. M12885 CAS No. 1868232-32-9
A-893 (A893) is a potent, selective and cell active lysine methyltransferase SMYD2 inhibitor with IC50 of 2.8 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameA-893
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NoteResearch use only, not for human use.
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Brief DescriptionA-893 (A893) is a potent, selective and cell active lysine methyltransferase SMYD2 inhibitor with IC50 of 2.8 nM.
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DescriptionA-893 (A893) is a potent, selective and cell active lysine methyltransferase SMYD2 inhibitor with IC50 of 2.8 nM; displays high selectivity against a panel of 31 other methyltransferases (<50% inhibition at 1 uM); reduces p53K370me1 without effects on overall p53 levels in A549 p53 cellular assay, has unexpectedly notable improvement in potency (>80-fold) compared with AZ-505 .
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SynonymsA 893;A893
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorHMTase
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1868232-32-9
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Formula Weight577.55
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Molecular FormulaC29H38Cl2N4O4
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(N1)COC(C1=CC=C2)=C2[C@@H](O)CNCCN(C3CCCCC3)C(CCNCCC4=CC(Cl)=C(Cl)C=C4)=O
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Chemical Name(R)-N-Cyclohexyl-3-[(3,4-dichlorophenethyl)amino]-N-[2-[[2-hydroxy-2-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl]amino]ethyl]propanamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sweis RF, et al. ACS Med Chem Lett. 2015 Apr 29;6(6):695-700.
molnova catalog
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