A-893 ( A 893;A893 )

Catalog No. M12885 CAS No. 1868232-32-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

A-893
Note

Research use only, not for human use.
Brief Description

A-893 (A893) is a potent, selective and cell active lysine methyltransferase SMYD2 inhibitor with IC50 of 2.8 nM.
Description

A-893 (A893) is a potent, selective and cell active lysine methyltransferase SMYD2 inhibitor with IC50 of 2.8 nM; displays high selectivity against a panel of 31 other methyltransferases (<50% inhibition at 1 uM); reduces p53K370me1 without effects on overall p53 levels in A549 p53 cellular assay, has unexpectedly notable improvement in potency (>80-fold) compared with AZ-505 .
Synonyms

A 893;A893
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

Cancer
Indication

——

CAS Number

1868232-32-9
Formula Weight

577.55
Molecular Formula

C29H38Cl2N4O4
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(N1)COC(C1=CC=C2)=C2[C@@H](O)CNCCN(C3CCCCC3)C(CCNCCC4=CC(Cl)=C(Cl)C=C4)=O
Chemical Name

(R)-N-Cyclohexyl-3-[(3,4-dichlorophenethyl)amino]-N-[2-[[2-hydroxy-2-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl]amino]ethyl]propanamide

1. Sweis RF, et al. ACS Med Chem Lett. 2015 Apr 29;6(6):695-700.

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