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A-381393
CAS No. 726174-00-1
A-381393( —— )
Catalog No. M20141 CAS No. 726174-00-1
A-381393 is a selective and brain penetrate dopamine D4 receptor antagonist (Kis: 1.9/1.5/1.6 nM for human dopamine D4.2/D4.4/D4.7 receptor).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 71 | In Stock |
|
| 5MG | 110 | In Stock |
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| 10MG | 178 | In Stock |
|
| 25MG | 332 | In Stock |
|
| 50MG | 478 | In Stock |
|
| 100MG | 691 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameA-381393
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NoteResearch use only, not for human use.
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Brief DescriptionA-381393 is a selective and brain penetrate dopamine D4 receptor antagonist (Kis: 1.9/1.5/1.6 nM for human dopamine D4.2/D4.4/D4.7 receptor).
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DescriptionA-381393 is a selective and brain penetrate dopamine D4 receptor antagonist (Kis: 1.9/1.5/1.6 nM for human dopamine D4.2/D4.4/D4.7 receptor).
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In VitroA-381393 exhibits weak affinity at 5-HT1A, Sigma 2, Adenoceptor α1A, Adenoceptor α2C, Histamine H1, with Kis of 1365, 8600, 2044, 1912 and 2962 nM, respectively.
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In Vivo——
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Synonyms——
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PathwayGPCR/G Protein
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TargetDopamine Receptor
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RecptorD4
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Research Area——
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Indication——
Chemical Information
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CAS Number726174-00-1
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Formula Weight320.43
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Molecular FormulaC20H24N4
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Purity>98% (HPLC)
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SolubilityDMSO: 50 mg/mL (156.04 mM)
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SMILESCc1ccc(cc1C)N1CCN(Cc2nc3ccccc3[nH]2)CC1
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Chemical Name2-[[4-(34-dimethylphenyl)piperazin-1-yl]methyl]-1H-benzimidazole
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Nakane M et al. 2-[4-(34-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393) a selective dopamine D4 receptor antagonist. Neuropharmacology. 2005 Jul;49(1):112-21.
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