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A-381393

CAS No. 726174-00-1

A-381393( —— )

Catalog No. M20141 CAS No. 726174-00-1

A-381393 is a selective and brain penetrate dopamine D4 receptor antagonist (Kis: 1.9/1.5/1.6 nM for human dopamine D4.2/D4.4/D4.7 receptor).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    A-381393
  • Note
    Research use only, not for human use.
  • Brief Description
    A-381393 is a selective and brain penetrate dopamine D4 receptor antagonist (Kis: 1.9/1.5/1.6 nM for human dopamine D4.2/D4.4/D4.7 receptor).
  • Description
    A-381393 is a selective and brain penetrate dopamine D4 receptor antagonist (Kis: 1.9/1.5/1.6 nM for human dopamine D4.2/D4.4/D4.7 receptor).
  • In Vitro
    A-381393 exhibits weak affinity at 5-HT1A, Sigma 2, Adenoceptor α1A, Adenoceptor α2C, Histamine H1, with Kis of 1365, 8600, 2044, 1912 and 2962 nM, respectively.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    D4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    726174-00-1
  • Formula Weight
    320.43
  • Molecular Formula
    C20H24N4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 50 mg/mL (156.04 mM)
  • SMILES
    Cc1ccc(cc1C)N1CCN(Cc2nc3ccccc3[nH]2)CC1
  • Chemical Name
    2-[[4-(34-dimethylphenyl)piperazin-1-yl]methyl]-1H-benzimidazole

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Nakane M et al. 2-[4-(34-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393) a selective dopamine D4 receptor antagonist. Neuropharmacology. 2005 Jul;49(1):112-21.
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