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Home - Products - Chromatin/Epigenetic - HMTase - A-366

A-366

CAS No. 1527503-11-2

A-366 ( A366 )

Catalog No. M12140 CAS No. 1527503-11-2

A-366 is a potent, highly selective inhibitor of histone methyltransferase G9a/GLP with IC50 of 3/38 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    A-366
  • Note
    Research use only, not for human use.
  • Brief Description
    A-366 is a potent, highly selective inhibitor of histone methyltransferase G9a/GLP with IC50 of 3/38 nM.
  • Description
    A-366 is a potent, highly selective inhibitor of histone methyltransferase G9a/GLP with IC50 of 3/38 nM, >1,000-fold selectivity for G9a over 21 other methyltransferases; effects a clear reduction in H3K9 methylation in cells, shows significantly less cytotoxic effects on the growth of tumor cell lines compared to other known G9a/GLP small molecule inhibitors despite equivalent cellular activity on methylation of H3K9me2 (H3K9me2 cellular EC50=0.3 uM); induces differentiation and affects viability in MV4;11 cells, demonstrates growth inhibition in vivo consistent with the profile of H3K9me2 reduction in flank xenograft leukemia model.
  • Synonyms
    A366
  • Pathway
    Chromatin/Epigenetic
  • Target
    HMTase
  • Recptor
    G9a/GLP
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    1527503-11-2
  • Formula Weight
    329.44
  • Molecular Formula
    C19H27N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    NC(C12CCC1)=NC3=C2C=C(OC)C(OCCCN4CCCC4)=C3
  • Chemical Name
    Spiro[cyclobutane-1,3'-[3H]indol]-2'-amine, 5'-methoxy-6'-[3-(1-pyrrolidinyl)propoxy]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sweis RF, et al. ACS Med Chem Lett. 2014 Jan 2;5(2):205-9.
2. Pappano WN, et al. PLoS One. 2015 Jul 6;10(7):e0131716.
3. Agarwal P, et al. Cancer Lett. 2016 Oct 1;380(2):467-75.
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