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BRD-4770
CAS No. 1374601-40-7
BRD-4770 ( BRD 4770;BRD4770 )
Catalog No. M11547 CAS No. 1374601-40-7
A SAM mimetic that selectively inhibits a subset of Histone Methyltransferase (HMTs).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 27 | In Stock |
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| 5MG | 43 | In Stock |
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| 10MG | 69 | In Stock |
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| 25MG | 115 | In Stock |
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| 50MG | 186 | In Stock |
|
| 100MG | 332 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBRD-4770
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NoteResearch use only, not for human use.
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Brief DescriptionA SAM mimetic that selectively inhibits a subset of Histone Methyltransferase (HMTs).
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DescriptionA SAM mimetic that selectively inhibits a subset of Histone Methyltransferase (HMTs), including G9a, in biochemical assays and in cells; decreases H3K9 trimethylation level in PANC-1 cells with EC50 of 5 uM; induces senescence, and inhibits both anchorage-dependent and -independent proliferation in PANC-1 cells; also increases LC3-II levels and the autophagosome number in PANC-1 cells combined with Gossypol.
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SynonymsBRD 4770;BRD4770
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorG9a
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1374601-40-7
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Formula Weight413.47
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Molecular FormulaC25H23N3O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(C1=CC=C2C(N=C(NC(C3=CC=CC=C3)=O)N2CCCC4=CC=CC=C4)=C1)OC
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Chemical Name1H-Benzimidazole-5-carboxylic acid, 2-(benzoylamino)-1-(3-phenylpropyl)-, methyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yuan Y, et al. ACS Chem Biol. 2012 Jul 20;7(7):1152-7.
2. Yuan Y, et al. Cell Death Dis. 2013 Jun 27;4:e690.
3. Zhang X, et al. Toxicol Appl Pharmacol. 2016 Aug 1;304:42-7.
2. Yuan Y, et al. Cell Death Dis. 2013 Jun 27;4:e690.
3. Zhang X, et al. Toxicol Appl Pharmacol. 2016 Aug 1;304:42-7.
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