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BRD-4770

CAS No. 1374601-40-7

BRD-4770 ( BRD 4770;BRD4770 )

Catalog No. M11547 CAS No. 1374601-40-7

A SAM mimetic that selectively inhibits a subset of Histone Methyltransferase (HMTs).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BRD-4770
  • Note
    Research use only, not for human use.
  • Brief Description
    A SAM mimetic that selectively inhibits a subset of Histone Methyltransferase (HMTs).
  • Description
    A SAM mimetic that selectively inhibits a subset of Histone Methyltransferase (HMTs), including G9a, in biochemical assays and in cells; decreases H3K9 trimethylation level in PANC-1 cells with EC50 of 5 uM; induces senescence, and inhibits both anchorage-dependent and -independent proliferation in PANC-1 cells; also increases LC3-II levels and the autophagosome number in PANC-1 cells combined with Gossypol.
  • Synonyms
    BRD 4770;BRD4770
  • Pathway
    Chromatin/Epigenetic
  • Target
    HMTase
  • Recptor
    G9a
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1374601-40-7
  • Formula Weight
    413.47
  • Molecular Formula
    C25H23N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(C1=CC=C2C(N=C(NC(C3=CC=CC=C3)=O)N2CCCC4=CC=CC=C4)=C1)OC
  • Chemical Name
    1H-Benzimidazole-5-carboxylic acid, 2-(benzoylamino)-1-(3-phenylpropyl)-, methyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yuan Y, et al. ACS Chem Biol. 2012 Jul 20;7(7):1152-7.
2. Yuan Y, et al. Cell Death Dis. 2013 Jun 27;4:e690.
3. Zhang X, et al. Toxicol Appl Pharmacol. 2016 Aug 1;304:42-7.
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