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A-1331852

CAS No. 1430844-80-6

A-1331852 ( A1331852;A 1331852 )

Catalog No. M11823 CAS No. 1430844-80-6

A-1331852 is a potent and selective BCL-XL inhibitor (Ki<10 pM); shows much weaker affinity for BCL-2 (Ki=6 nM), BCL-W (Ki=4 nM), and MCL-1 (Ki=142 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    A-1331852
  • Note
    Research use only, not for human use.
  • Brief Description
    A-1331852 is a potent and selective BCL-XL inhibitor (Ki<10 pM); shows much weaker affinity for BCL-2 (Ki=6 nM), BCL-W (Ki=4 nM), and MCL-1 (Ki=142 nM).
  • Description
    A-1331852 is a potent and selective BCL-XL inhibitor (Ki<10 pM); shows much weaker affinity for BCL-2 (Ki=6 nM), BCL-W (Ki=4 nM), and MCL-1 (Ki=142 nM); selectively disrupts BCL-XL–BIM complexes and induces the hallmarks of apoptosis in BCL-XL–dependent Molt-4 cells (Molt-4 viability IC50=6 nM); demonstrates antitumor efficacy in the Molt-4 xenograft model; orally active.
  • Synonyms
    A1331852;A 1331852
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Bcl-2;Bcl-w;Bcl-xL;Mcl-1
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    1430844-80-6
  • Formula Weight
    658.81
  • Molecular Formula
    C38H38N6O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 12 mg/mL
  • SMILES
    CC1=C(C=NN1CC23CC4CC(C2)CC(C4)C3)C5=C(N=C(C=C5)N6CCC7=CC=CC(=C7C6)C(=O)NC8=NC9=CC=CC=C9S8)C(=O)O
  • Chemical Name
    2-Pyridinecarboxylic acid, 6-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Leverson JD, et al. Sci Transl Med. 2015 Mar 18;7(279):279ra40.
2. Punnoose EA, et al. Mol Cancer Ther. 2016 May;15(5):1132-44.
3. Lucas CM, et al. Leukemia. 2016 Jun;30(6):1273-81.
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