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8-M-PDOT

CAS No. 134865-70-6

8-M-PDOT( —— )

Catalog No. M32761 CAS No. 134865-70-6

8-M-PDOT (AH-002) is a selective and potent melatonin MT2 receptor agonist that also inhibits MT1 receptors. 8-M-PDOT exhibits anxiolytic activity and can be used to study MT2-induced neuropathic pain.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    8-M-PDOT
  • Note
    Research use only, not for human use.
  • Brief Description
    8-M-PDOT (AH-002) is a selective and potent melatonin MT2 receptor agonist that also inhibits MT1 receptors. 8-M-PDOT exhibits anxiolytic activity and can be used to study MT2-induced neuropathic pain.
  • Description
    8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity.
  • In Vitro
    ——
  • In Vivo
    8-M-PDOT (10 μg/μL; administrated into the dorsal striatum by bilateral cannulas; for 30 minutes; male Wistar rats) treatment shows anxiolytic-like effect.Animal Model:Male Wistar rats (280-320 g) with Rotenone Dosage:10 μg/μL Administration: Administrated into the dorsal striatum by bilateral cannulas; for 30 minutes Result:Increased percentage of time spent in the open arms and in the number of open arms entries.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    MT Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    134865-70-6
  • Formula Weight
    233.31
  • Molecular Formula
    C14H19NO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (428.61 mM; Ultrasonic )
  • SMILES
    CCC(=O)NC1CCc2cccc(OC)c2C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Browning C, et al. Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors. Br J Pharmacol. 2000 Mar;129(5):877-86.?
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