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740 Y-P
CAS No. 1236188-16-1
740 Y-P( 740YPDGFR | PDGFR 740Y-P )
Catalog No. M23412 CAS No. 1236188-16-1
740 Y-P is a potent and cell-permeable activator of PI3K.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 239 | In Stock |
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| 10MG | 354 | In Stock |
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| 25MG | 557 | In Stock |
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| 50MG | 789 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Name740 Y-P
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NoteResearch use only, not for human use.
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Brief Description740 Y-P is a potent and cell-permeable activator of PI3K.
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Description740 Y-P is a potent and cell-permeable activator of PI3K.
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In Vitro740 Y-P (50 μg/mL; 48 hours) specificly stimulates mitogenesis in medium is better than EGF or FGF at stimulating entry into S-phase, it shows the percentage of cells in S-phase for 48.3% in C2 cells. Additionally, LY294002 (HY-10108) or Wortmannin (HY-10197) potently inhibits the mitogenic response stimulated by the peptide.740 Y-P (1 μg/mL) stimulates mitogenesis at the lowest concentration tested. The peptide stimulates mitogenesis in both the presence and absence of serum (0.5%), and in the former instance a maximal response observed at 50 μg/mL. 740Y-P to stimulate mitogenesis is highly specific and not a general feature of a cell permeable SH2 domain binding peptides.740 Y-P (30 μM; 24 hours) remarkably inhibits the level of LC3-II/LC3-I in GO-induced PC12 cells. Western Blot Analysis Cell Line:PC12 cells Concentration:30 μM Incubation Time:24 hours Result:Inhibited the protein expression of LC3-II.
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In Vivo740 Y-P is not only internalised in living cells but can also interact with p85 in vivo.740 Y-P (intraperitoneal?injection; 10 mg/kg; 6 weeks) decreases the degree of ROS levels in Aβ(25-32) treated hippocampaltissues and increases the extent of AKT and PI3K phosphorylation in alzheimer’s disease (AD) rat model.
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Synonyms740YPDGFR | PDGFR 740Y-P
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PathwayAutophagy
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TargetAutophagy
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RecptorAutophagy|PI3K
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Research Area——
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Indication——
Chemical Information
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CAS Number1236188-16-1
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Formula Weight3270.72
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Molecular FormulaC141H222N43O39PS3
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Purity>98% (HPLC)
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SolubilityWater:15 mg/mL (4.58 mM)
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SMILESCC[C@H](C)[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC4=CNC5=CC=CC=C54)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CC6=CC=C(C=C6)OP(=O)(O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCNC(=N)N)N
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Derossi D, et al. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. Biochem Biophys Res Commun. 1998 Oct 9;251(1):148-52.
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