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6-Chloromelatonin

CAS No. 63762-74-3

6-Chloromelatonin( —— )

Catalog No. M33826 CAS No. 63762-74-3

6-Chloromelatonin is a potent melatonin receptor agonist, a 5-methoxyindole compound that competes for presynaptic melatonin receptor sites in the rabbit retina, inhibiting the calcium-dependent release of [3H]dopamine with higher metabolic stability than melatonin.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    6-Chloromelatonin
  • Note
    Research use only, not for human use.
  • Brief Description
    6-Chloromelatonin is a potent melatonin receptor agonist, a 5-methoxyindole compound that competes for presynaptic melatonin receptor sites in the rabbit retina, inhibiting the calcium-dependent release of [3H]dopamine with higher metabolic stability than melatonin.
  • Description
    6-Chloromelatonin is a potent melatonin receptor agonist with greater metabolic stability than melatonin. 6-Chloromelatonin compete for [3H]-melatonin and 2-[125I]-iodomelatonin binding to MT1 receptors (pKi=8.9 and 9.1, respectively). 6-Chloromelatonin compete for [3H]-melatonin binding to MT2 receptors (pKi=9.77).
  • In Vitro
    6-Chloromelatonin competes for [3H]-melatonin binding sites in human platelet (Ki=11.4 nM). 6-chloromelatonin (10 pM, 1 nM, 100 nM, 10 μM; 72 hours) inhibits, in a dose-dependent manner, forskolin-stimulated hCG-beta secretion in JEG-3 and BeWo cells but had no effect on basal human chorionic gonadotrophin (hCG-beta) levels.
  • In Vivo
    Rats injected with the melatonin agonist, 6-chloromelatonin (0.5 mg/kg) on the day after the phase shift has markedly higher excretion rates of 6-sulphatoxymelatonin compared to those of the controls.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Melatonin Receptor
  • Recptor
    Melatonin Receptor | Dopamine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    63762-74-3
  • Formula Weight
    266.72
  • Molecular Formula
    C13H15ClN2O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(CNC(C)=O)C=1C=2C(=CC(Cl)=C(OC)C2)NC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Browning C, et al. Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors. Br J Pharmacol. 2000;129(5):877-886.?
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