Cart
sales@molnova.com
Home - Products - GPCR/G Protein - Melatonin Receptor - 2-Iodomelatonin

2-Iodomelatonin

CAS No. 93515-00-5

2-Iodomelatonin( —— )

Catalog No. M32743 CAS No. 93515-00-5

2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, exhibiting over 5-fold selectivity for MT1 compared to MT2.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
10MG 36 In Stock
25MG 70 In Stock
50MG 117 In Stock
100MG 178 In Stock
200MG 267 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    2-Iodomelatonin
  • Note
    Research use only, not for human use.
  • Brief Description
    2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, exhibiting over 5-fold selectivity for MT1 compared to MT2.
  • Description
    2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, it is more 5-fold selective for MT1 ?over MT2. 2-iodomelatonin can be used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.
  • In Vitro
    2-iodomelatonin (0-7.5 μM; 18 hours) sharesthe protective properties of melatonin, it inhibits cell death of mutant htt ST14A and inhibits the increase in Rip2 expression in stressed mutant htt ST14A cells.Cell Viability Assay Cell Line:Mutant htt ST14A cell Concentration:0 μM; 1 μM; 5 μM; 7.5 μM Incubation Time:18 hours Result:Inhibited mutant htt ST14A cell death.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Melatonin Receptor
  • Recptor
    Melatonin Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    93515-00-5
  • Formula Weight
    358.17
  • Molecular Formula
    C13H15IN2O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMF : 30 mg/mL (83.76 mM) DMSO: 30 mg/mL (83.76 mM)Ethanol : 20 mg/mL (55.84 mM)
  • SMILES
    COc1ccc2[nH]c(I)c(CCNC(C)=O)c2c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tomkinson A, et al. A murine IL-4 receptor antagonist that inhibits IL-4- and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness. J Immunol. 2001 May 1;166(9):5792-800.?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • 6-Chloromelatonin

    6-Chloromelatonin is a potent melatonin receptor agonist, a 5-methoxyindole compound that competes for presynaptic melatonin receptor sites in the rabbit retina, inhibiting the calcium-dependent release of [3H]dopamine with higher metabolic stability than melatonin.

  • Acotiamide hydrochlo...

    Acotiamide Hydrochloride is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity.

  • Agomelatine

    A melatonin receptor agonist of MT1 (Ki=0.1nM) and MT2 (Ki=0.12nM), and a 5-HT2C (Ki=631nM) receptor antagonist.

Sign In Join Free