6-AZATHYMINE( —— )

Catalog No. M22531 CAS No. 932-53-6

6-azathymine is a potent inhibitors of D-3-aminoisobutyrate-pyruvate aminotransferase.?6-Azauracil acted as a competitive inhibitor with respect to beta-alanine, and was an uncompetitive inhibitor with respect to pyruvic acid with a Ki of approximately 8.9 mM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

6-AZATHYMINE
Note

Research use only, not for human use.
Brief Description

6-azathymine is a potent inhibitors of D-3-aminoisobutyrate-pyruvate aminotransferase.?6-Azauracil acted as a competitive inhibitor with respect to beta-alanine, and was an uncompetitive inhibitor with respect to pyruvic acid with a Ki of approximately 8.9 mM.
Description

6-azathymine is a potent inhibitors of D-3-aminoisobutyrate-pyruvate aminotransferase.?6-Azauracil acted as a competitive inhibitor with respect to beta-alanine, and was an uncompetitive inhibitor with respect to pyruvic acid with a Ki of approximately 8.9 mM.
In Vitro

6-Azathymine is a competitive antagonist of the growth of Streptococcus faecalis (8043) and several other strains of microorganisms. Studies of the mechanism of action of 6-Azathymine reveal that S. faecalis can convert the analog to the corresponding deoxyriboside, azathymidine.
In Vivo

The administration of 6-Azathymine to the mouse leads to the urinary elimination not only of free Azathymine, but also of various metabolites of it. Following the administration of 6-Azathymine-5-14C to mice, radioactivity is found in all tissues investigated, not only in the form of free Azathymine, but also as metabolic derivatives.
Synonyms

——
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Bacterial
Research Area

——
Indication

——

Chemical Information

CAS Number

932-53-6
Formula Weight

127.1
Molecular Formula

C4H5N3O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (983.48 mM)
SMILES

Cc1n[nH]c(=O)[nH]c1=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. N Tamaki, et al. Purification, Characterization and Inhibition of D-3-aminoisobutyrate Aminotransferase From the Rat Liver. Eur J Biochem. 1990 Apr 20;189(1):39-45.

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