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5-Ph-IAA

CAS No. 168649-23-8

5-Ph-IAA( —— )

Catalog No. M23758 CAS No. 168649-23-8

5-Ph-IAA is a derivative of Indole-3-acetic acid (IAA), which is a plant hormone and acts as an enzyme or prodrug combination for cancer gene therapy.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    5-Ph-IAA
  • Note
    Research use only, not for human use.
  • Brief Description
    5-Ph-IAA is a derivative of Indole-3-acetic acid (IAA), which is a plant hormone and acts as an enzyme or prodrug combination for cancer gene therapy.
  • Description
    5-Ph-IAA is a derivative of Indole-3-acetic acid (IAA), which is a plant hormone and acts as an enzyme or prodrug combination for cancer gene therapy.
  • In Vitro
    Western Blot Analysis Cell Line:HCT116 cells Concentration:1 μM Incubation Time:6 hours Result:Depleted DHC1-mAC efficiently in HCT116 cells constitutively expressing OsTIR1(F74G).
  • In Vivo
    Animal Model:Balb/c-nu female mice (7 weeks old; 16–20?g ) bearing mAID-BRD4 and TOP2A-mAC xenograft tumours cells Dosage:0 mg/kg, 1 mg/kg, 3 mg/kg and 10?mg/kg Administration:Intraperitoneally injection; every day; 7 days Result:Displayed significant tumour suppression of mAID-BRD4 xenografts and TOP2A-mAC xenografts.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    168649-23-8
  • Formula Weight
    251.28
  • Molecular Formula
    C16H13NO2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL?(497.45 mM;?Need ultrasonic)
  • SMILES
    C1=CC=C(C=C1)C2=CC3=C(C=C2)NC=C3CC(=O)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.O Greco,et al. Horseradish peroxidase-mediated gene therapy: choice of prodrugs in oxic and anoxic tumor conditions. Mol Cancer Ther. 2001 Dec;1(2):151-60.
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