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5-Nitro-110-phenanthroline

CAS No. 4199-88-6

5-Nitro-110-phenanthroline( 5-NP )

Catalog No. M20958 CAS No. 4199-88-6

5-Nitro-110-phenanthroline(5-NP) is a potent bactericidal agent and inhibiting Clostridium difficile.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    5-Nitro-110-phenanthroline
  • Note
    Research use only, not for human use.
  • Brief Description
    5-Nitro-110-phenanthroline(5-NP) is a potent bactericidal agent and inhibiting Clostridium difficile.
  • Description
    5-Nitro-110-phenanthroline(5-NP) is a potent bactericidal agent and inhibiting Clostridium difficile.
  • In Vitro
    5-Nitro-1,10-phenanthroline (25 μM; 24 h) kills naturally resistant intracellular bacteria by inducing autophagy in THP-1 macrophages. 5-Nitro-1,10-phenanthroline (1x, 5x, 20x or 50x MIC, MIC=0.78 μM; 1 h) also modulates the host machinery to kill intracellular pathogens by inhibiting mycolic acid biosynthesis of Mtb. Cell Viability Assay Cell Line:Mtb H37Rv, M. bovis BCG and M. bovis BCG-5NP resistant strain Concentration:0-12.5 μM Incubation Time:24 hours Result:Inhibited pathogens with MIC99 values of 0.78 μM (Mtb H37Rv), 0.78 μM (M. bovis BCG), and >12.5 μM (M. bovis BCG-5NP), respectively.
  • In Vivo
    ——
  • Synonyms
    5-NP
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Bacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    4199-88-6
  • Formula Weight
    225.2
  • Molecular Formula
    C12H7N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=[N+]([O-])c1cc2cccnc2c2ncccc12
  • Chemical Name
    5-Nitro-110-phenanthroline

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Liu H Robbins M Mehrotra A et al. The Impact of Using Mid-level Providers in Face-to-Face Primary Care on Health Care Utilization[J]. Medical care 2016 55(1).
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