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5-Hydroxyoxindole

CAS No. 3416-18-0

5-Hydroxyoxindole( —— )

Catalog No. M28142 CAS No. 3416-18-0

5-Hydroxyoxindole has been identified as a urinary metabolite of indole, which is produced from tryptophane via the tryptophanase activity of gut bacteria.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    5-Hydroxyoxindole
  • Note
    Research use only, not for human use.
  • Brief Description
    5-Hydroxyoxindole has been identified as a urinary metabolite of indole, which is produced from tryptophane via the tryptophanase activity of gut bacteria.
  • Description
    5-Hydroxyoxindole has been identified as a urinary metabolite of indole, which is produced from tryptophane via the tryptophanase activity of gut bacteria . 5-Hydroxyoxindole has lipid peroxidation inhibition activity and free radical DPPH scavenging.(In Vitro):5-Hydroxyoxindole was less potent MAO-A inhibitor (IC50 56.8 microM) than isatin (31.8 microM) and especially 5-hydroxyisatin (6.5 microM), but it was the only highly selective MAO-A inhibitor among the all compounds studied (IC50 MAO-A:IC50 MAO-B = 0.044) . (In Vivo):In blood plasma, 5-hydroxyoxindole levels were quite stable . The maximal 5-hydroxyoxindole concentration in plasma was: 5.4 nM (5-hydroxyoxindole molecular weight: 149) .
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Immunology/Inflammation
  • Target
    ROS
  • Recptor
    serotonin|Norepinephrine|Dopamine
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    3416-18-0
  • Formula Weight
    149.149
  • Molecular Formula
    C8H7NO2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Oc1ccc2NC(=O)Cc2c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Shao L, et al. Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1438-41.
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