N-tert-butyl-α-Phenylnitrone

Research use only, not for human use.

N-tert-butyl-α-Phenylnitrone inhibits COX2 catalytic activity.

N-tert-butyl-α-Phenylnitrone inhibits COX2 catalytic activity. N-tert-butyl-α-Phenylnitrone possesses potent reactive oxygen species scavenging, anti-inflammatory, neuroprotective, anti-aging, and anti-diabetic activities, and can penetrate the blood-brain barrier.(In Vitro):Treatment of 25-100 μM N-tert-butyl-α-Phenylnitrone significantly reduces 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH)-induced intracellular ROS accumulation. N-tert-butyl-α-Phenylnitrone also attenuates AAPH-induced cytotoxicity, matrix degradation, and apoptosis, inhibiting AAPH-induced ERK/MAPK pathway activation. (In Vivo):In C57Bl/6 mice induced by lipopolysaccharide (LPS), intraperitoneal injection of 100 mg/kg N-tert-butyl-α-Phenylnitrone twice a day (on gestational day 8) abolishes LPS-induced lipid peroxidation, nitrate tyrosine residue levels and GSH depletion, and reduces the incidence of external malformations.

(Z)-N-benzylidene-2-Methylpropan-2-aMine oxide

Immunology/Inflammation

ROS

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3376-24-7

177.2

C11H15NO

>98% (HPLC)

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CC(C)(C)[N+](\[O-])=C\c1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years