5-Chloro-2-deoxyuridine

Research use only, not for human use.

5-Chloro-2'-deoxyuridine is a thymine analog. It can be used to study the potential of hypochlorous acid damage to DNA and DNA precursors.

5-Chloro-2'-deoxyuridine is a thymine analog. It can be used to study the potential of hypochlorous acid damage to DNA and DNA precursors.(In Vitro):When 5-Chloro-2’-deoxyuridine (ClDU) is placed into the tissue culture medium, mammalian cells incorporate the analog into DNA. It is observed that a 10 μM concentration of 5-Chloro-2’-deoxyuridine in the media does not alter cell division kinetics. Previously it has been shown that 5-Chloro-2’-deoxyuridine is metabolized and incorporated into DNA using antibodies that bind selectively to DNA containing halogenated bases. In the studies reported here, 5-Chloro-2’-deoxyuridine is more similar to BrdU in acting as a T analog. The toxicity of 5-Chloro-2’-deoxyuridine could in part be attributed to inhibition of thymidylate synthase .

5-Chlorodeoxyuridine; CldU

Others

Other Targets

TRPM4

——

——

50-90-8

262.7

C9H11ClN2O5

>98% (HPLC)

——

OC[C@H]1O[C@H](C[C@@H]1O)n1cc(Cl)c(=O)[nH]c1=O

——

(-20℃)

With Ice Pack

≥ 2 years