HMN-176
CAS No. 173529-10-7
HMN-176 ( HMN176; HMN 176; HMN-176 )
Catalog No. M17369 CAS No. 173529-10-7
HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 46 | In Stock |
|
5MG | 72 | In Stock |
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10MG | 110 | In Stock |
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25MG | 178 | In Stock |
|
50MG | 332 | In Stock |
|
100MG | 494 | In Stock |
|
500MG | 1071 | In Stock |
|
1G | Get Quote | In Stock |
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Biological Information
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Product NameHMN-176
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NoteResearch use only, not for human use.
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Brief DescriptionHMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).
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DescriptionHMN-176 is an active metabolite of the synthetic antitumor compound HMN-214. HMN-176 shows potent cytotoxicity toward various human tumor cell lines, and in mitotic cells, it causes cell cycle arrest at M phase through the destruction of spindle polar bodies, followed by the induction of DNA fragmentation. However, no direct interactions of HMN-176 with tubulin are observed. Moreover, in animal models, it was observed that oral administration of the prodrug HMN-214 caused no significant nerve toxicity, a severe side effect often associated with microtubule binding agents such as Taxol and VCR.3 In Phase I clinical trials, HMN-214 has caused sensory neuropathy and ileus in some patients. However, the grade and frequency of these adverse effects were much lower than those of typical microtubule binding agents. As expected from the mechanism of action of HMN-214 (induction of G2-M arrest in dividing cells), the main adverse effect was neutropenia.
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SynonymsHMN176; HMN 176; HMN-176
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number173529-10-7
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Formula Weight382.43
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Molecular FormulaC20H18N2O4S
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Purity98%
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Solubility——
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SMILESO=S(=O)(c1ccc(OC)cc1)Nc1ccccc1/C=C/c1cc[n+](cc1)[O-]
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Chemical Name(E)-4-(2-(4-methoxyphenylsulfonamido)styryl)pyridine 1-oxide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. DiMaio MA, et al. Mol Y Ther. 2009 Mar;8(3):592-601.
molnova catalog
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