HMN-176

CAS No. 173529-10-7

HMN-176 ( HMN176; HMN 176; HMN-176 )

Catalog No. M17369 CAS No. 173529-10-7

HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 46 In Stock
5MG 72 In Stock
10MG 110 In Stock
25MG 178 In Stock
50MG 332 In Stock
100MG 494 In Stock
500MG 1071 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    HMN-176
  • Note
    Research use only, not for human use.
  • Brief Description
    HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).
  • Description
    HMN-176 is an active metabolite of the synthetic antitumor compound HMN-214. HMN-176 shows potent cytotoxicity toward various human tumor cell lines, and in mitotic cells, it causes cell cycle arrest at M phase through the destruction of spindle polar bodies, followed by the induction of DNA fragmentation. However, no direct interactions of HMN-176 with tubulin are observed. Moreover, in animal models, it was observed that oral administration of the prodrug HMN-214 caused no significant nerve toxicity, a severe side effect often associated with microtubule binding agents such as Taxol and VCR.3 In Phase I clinical trials, HMN-214 has caused sensory neuropathy and ileus in some patients. However, the grade and frequency of these adverse effects were much lower than those of typical microtubule binding agents. As expected from the mechanism of action of HMN-214 (induction of G2-M arrest in dividing cells), the main adverse effect was neutropenia.
  • Synonyms
    HMN176; HMN 176; HMN-176
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    173529-10-7
  • Formula Weight
    382.43
  • Molecular Formula
    C20H18N2O4S
  • Purity
    98%
  • Solubility
    ——
  • SMILES
    O=S(=O)(c1ccc(OC)cc1)Nc1ccccc1/C=C/c1cc[n+](cc1)[O-]
  • Chemical Name
    (E)-4-(2-(4-methoxyphenylsulfonamido)styryl)pyridine 1-oxide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. DiMaio MA, et al. Mol Y Ther. 2009 Mar;8(3):592-601.
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