5,6-Dihydroxyindole

Research use only, not for human use.

5,6-Dihydroxyindole (Dopamine lutine) is a melanin precursor and has a broad-spectrum antibacterial, antiviral, antifungal, antiparasitic activity.

5,6-Dihydroxyindole, a melanin precursor, has a broad-spectrum antibacterial, antifungal, antiviral, antiparasitic activity. 5,6-Dihydroxyindole has cytotoxic effects and is strongly toxic against various pathogens.

5,6-Dihydroxyindole (1, 10, 20, 50, 100 μM; for 4 hours) dose-dependently decreases OD492 values. Pretreatment of Sf9 cells with 1.0 mM 5,6-Dihydroxyindole for 4 hours results in 97% mortality, and LC50 values of 20.3 μM in buffer and 131.8 μM in a culture medium. Preincubation of a baculovirus stock with 1.25 mM 5,6-Dihydroxyindole for 3 hours near fully disables recombinant protein production. The LC50 for lambda bacteriophage and eggs of the wasp Microplitis demolitor are 5.6 and 111.0 μM, respectively. 5,6-Dihydroxyindole and its spontaneous oxidation products are also active against viruses and parasitic wasps.

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Proteasome/Ubiquitin

Endogenous Metabolite

Endogenous Metabolite

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3131-52-0

149.15

C8H7NO2

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (335.23 mM; Ultrasonic ) H2O : < 0.1 mg/mL (insoluble)

Oc1cc2cc[nH]c2cc1O

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(-20℃)

With Ice Pack

≥ 2 years