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eIF4A3-IN-1q

CAS No. 2132392-89-1

eIF4A3-IN-1q( —— )

Catalog No. M13396 CAS No. 2132392-89-1

A potent, subtype-selective, orally available eIF4A3 inhibitor with IC50 of 0.14 uM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    eIF4A3-IN-1q
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, subtype-selective, orally available eIF4A3 inhibitor with IC50 of 0.14 uM.
  • Description
    A potent, subtype-selective, orally available eIF4A3 inhibitor with IC50 of 0.14 uM; displays no activity against eIF4A1, eIF4A2, BRR2 and DHX29 (IC50>100 uM); upregulates SC35 1.6 kb mRNA expression by 8-fold at 3 uM and 20-fold at 10 uM, potently inhibit cell growth in HCT-116 cells (GI50=1.18 uM) ; shows antitumor efficacy and promising PK profiles in vivo, without severe body weight loss.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Nuclear Receptor/Transcription Factor
  • Target
    eIF
  • Recptor
    eIF
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2132392-89-1
  • Formula Weight
    645.861
  • Molecular Formula
    C29H21BrClF3N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1CN(C(CN1C(=O)C2=CN(C(=O)C(=C2)C(F)(F)F)C3=CC=CC=C3)C4=CC=C(C=C4)Cl)C(=O)C5=NC=C(C=C5)Br
  • Chemical Name
    (S)-5-(4-(5-bromopicolinoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl)-1-phenyl-3-(trifluoromethyl)pyridin-2(1H)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mizojiri R, et al. ACS Med Chem Lett. 2017 Sep 8;8(10):1077-1082.
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