Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 and NF-?oB pathways, and may be a valuable compound to prevent or treat inflammatory diseases.

3'-?O-?Acetylhamaudol, isolated from the roots of Angelica japonica, exhibits anti-tumor activity through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation.

Dimethylamine (DMA) is abundantly present in human urine. Main sources of urinary DMA have been reported to include trimethylamine N-oxide a common food component and asymmetric dimethylarginine (ADMA) an endogenous inhibitor of nitric oxide (NO) synthesis.