LB42708 ( LB42708; LB-42708; LB 42708 )

Catalog No. M17445 CAS No. 226929-39-1

COA

Datasheet

HNMR

HPLC

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Product Name

LB42708
Note

Research use only, not for human use.
Brief Description

LB42708 is an orally active farnesyltransferase (FTase) inhibitor (IC50: 0.8/1.2/2.0 nM toward H/N/K-ras).
Description

LB42708 is a potent, orally active and selective nonpeptidic farnesyltransferase inhibitor (FTase inhibitor). LB42708 inhibited VEGF-induced Ras activation and subsequently suppressed angiogenesis in vitro and in vivo by blocking the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase/p38 mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric-oxide synthase pathways in endothelial cells without altering FAK/Src activation.
Synonyms

LB42708; LB-42708; LB 42708
Pathway

Others
Target

Other Targets
Recptor

Farnesyl transferase (FTase); Farnesyl transferase (FTase); Farnesyl transferase (FTase)
Research Area

Cancer
Indication

——

CAS Number

226929-39-1
Formula Weight

555.46
Molecular Formula

C30H27BrN4O2
Purity

98%
Solubility

——
SMILES

Brc1ccc(Cn2cncc2Cn2cc(C(=O)N3CCOCC3)c(c2)c2cccc3ccccc23)cc1
Chemical Name

(1-((1-(4-bromobenzyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(morpholino)methanone

1. Na HJ, et al. J Immunol. 2004, 173(2), 1276-1283.

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