4-P-PDOT( 4-phenyl-2- propionamidotetralin )

Catalog No. M23510 CAS No. 134865-74-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

4-P-PDOT
Note

Research use only, not for human use.
Brief Description

4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist.
Description

4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist.
In Vitro

Cell Viability Assay Cell Line:HT-29 and HeLa cells.Concentration:50 μM Incubation Time:30 min Result:Produced a negligible effect on cell viability induced by melatonin.
In Vivo

Animal Model:Klotho mutant mice treatment with Melatonin Dosage:0.5 mg/kg or 1.0 mg/kg Administration:Intravenous injection Result:Significantly reversed antioxidant effects mediated by Melatonin. Significantly reversed the changes in the levels of these GSH-related parameters. Significantly reversed the memory function of Melatonin-treated klotho mutant mice.
Synonyms

4-phenyl-2- propionamidotetralin
Pathway

Others
Target

Other Targets
Recptor

MT2 receptor
Research Area

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Indication

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1.Dubocovich ML. Melatonin receptors: are there multiple subtypes? Trends Pharmacol Sci. 1995 Feb;16(2):50-6.

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