4-Hydroxynonenal

Research use only, not for human use.

4-Hydroxynonenal (4-HNE) is an oxidative/nitrosative stress biomarker. It is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2).

4-Hydroxynonenal (4-HNE) is an oxidative/nitrosative stress biomarker. It is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2).4-Hydroxynonenal is both a substrate and an inhibitor of ALDH2; inhibition of ALDH2 by 4-Hydroxynonenal is reversible at low concentration and becomes irreversible when the concentration of 4-HNE reaches 10 μM. 4-Hydroxynonenal can induce antioxidant defense mechanisms to restrain its own production and to enhance cellular protection against oxidative stress. 4-Hydroxynonenal, the product of lipid peroxidation, is mutagenic and genotoxic in viruses, bacteria, and mammalian cells. It reacts with all four DNA bases but with different efficiency: G >C > A >T. 4-Hydroxynonenal-dG represents the best biomarker of the genotoxic effects of 4-Hydroxynonenal and these adducts are primarily found in nuclear DNA [1].Following 24 h after fluid percussion injury (FPI), the mouse brain tissue is analyzed for the expression level of NADPH oxidase 1 (NOX1), inducible nitric oxide synthase (iNOS), 4-Hydroxynonenal (4-HNE. Both wild-type (Nrf2+/+) and Nrf2-deficient mice (Nrf2?/?) results in increased expression of 4-Hydroxynonenal following 15 psi injury (moderate injury) when compared to uninjured Nrf2+/+ and Nrf2?/? mice. Similar to the iNOS result, in Nrf2?/? KO mice, the expression level of 4-Hydroxynonenal is significantly high when compared to corresponding injured and uninjured Nrf2+/+ WT animals.

4-HNE

Proteasome/Ubiquitin

Endogenous Metabolite

Human Endogenous Metabolite;ALDH2

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75899-68-2

156.22

C9H16O2

>98% (HPLC)

DMSO:249 mg/mL(1593.91 mM)

CCCCCC(O)\C=C\C=O

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(-20℃)

With Ice Pack

≥ 2 years