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2OH-BNPP1
CAS No. 833481-73-5
2OH-BNPP1( —— )
Catalog No. M24823 CAS No. 833481-73-5
2OH-BNPP1 is a BUB1 kinase, a Ser/Thr kinase inhibitor, it used for the treatment of cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 81 | In Stock |
|
| 5MG | 145 | In Stock |
|
| 10MG | 255 | In Stock |
|
| 25MG | 525 | In Stock |
|
| 50MG | 750 | In Stock |
|
| 100MG | 1035 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Name2OH-BNPP1
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NoteResearch use only, not for human use.
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Brief Description2OH-BNPP1 is a BUB1 kinase, a Ser/Thr kinase inhibitor, it used for the treatment of cancer.
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Description2OH-BNPP1 is a BUB1 kinase, a Ser/Thr kinase inhibitor, it used for the treatment of cancer.
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In Vitro2OH-BNPP1 (0.1-50 μM) abrogates TGFβ signaling in a dose dependent manner. 2OH-BNPP1 dose-dependently impairs the TGFβ-induced phosphorylation of proteins that mediate canonical and non-canonical TGFβ signaling in multiple cancer cell lines and normal cell lines.
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In Vivo2OH-BNPP1 (50 mg/kg) blocks TGFβ signaling in vivo, and significantly decreases abundance of phosphorylated SMAD2 in tumor-bearing mice.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorBUB1 kinase
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Research Area——
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Indication——
Chemical Information
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CAS Number833481-73-5
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Formula Weight297.35
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Molecular FormulaC16H19N5O
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Purity>98% (HPLC)
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SolubilityDMSO: 100 mg/mL (336.30 mM)
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SMILESCC(C)(C)n1nc(Cc(cccc2)c2O)c2c(N)ncnc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Nyati S, et al. The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling. Sci Signal. 2015 Jan 6;8(358):ra1.
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