17α-Estradiol

Research use only, not for human use.

Endogenous estrogen receptor ligand (Ki?values are 0.2 and 1.2 nM for ERα?and ERβ?receptors respectively).

Endogenous estrogen receptor ligand (Ki?values are 0.2 and 1.2 nM for ERα?and ERβ?receptors respectively).

Alpha-Estradiol (17 alpha-Estradiol) is a 5α-reductase inhibitor, and inhibits testosterone metabolism catalyzed by 5 alpha-reductase. Alpha-Estradiol (17 Alpha-estradiol, 10 μM) attenuates LPS-induced inflammatory markers in both C57BL/6J male and female mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes and differentiated 3T3-L1 adipocytes in an ERα-dependent manner, and such effects are through decreased NFκB-p65 and increased ERα protein expression.

Alpha-Estradiol (17-alpha-estradiol, 0.01, 0.1, 1 μg) significantly reduces the percentage of central avascular/total retina area of the mouse pups. Alpha-Estradiol (1 μg) markedly decreasesmalondialdehyde (MDA) levels on postnatal days (PND) 9, 13, and 17 in retinas of hyperoxia-exposed pups. Alpha-Estradiol (1 μg) also decreases the number of NADPH-oxidase-positive cells, NADPH oxidase concentration and activity in retinas of the pups. In the 1.0-μg Alpha-Estradiol-treated pups, VEGF retinal concentrations are high on PND 9 but lower on PND 14 and 17. The best effect in retinas of 1.0-μg Alpha-Estradiol-treated pups is partly reversed by ICI182780 on PND 14 and 17.

Alfatradiol | Epiestradiol | Epiestrol

Endocrinology/Hormones

5-HT Receptor

ERα| ERβ

Others-Field

——

57-91-0

272.38

C18H24O2

>98% (HPLC)

DMSO : 103.3 mg/mL 379.25 mM

c1cc(cc2CC[C@H]3[C@@H]4CC[C@H]([C@]4(CC[C@@H]3c12)C)O)O

——

(-20℃)

With Ice Pack

≥ 2 years