11-Beta-hydroxyandrostenedione

CAS No. 382-44-5

11-Beta-hydroxyandrostenedione ( 4-Androsten-11β-ol-3,17-dione; NSC-17102 )

Catalog No. M26588 CAS No. 382-44-5

11-Beta-hydroxyandrostenedione is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    11-Beta-hydroxyandrostenedione
  • Note
    Research use only, not for human use.
  • Brief Description
    11-Beta-hydroxyandrostenedione is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue).
  • Description
    11-Beta-hydroxyandrostenedione is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue), which is a 11β-hydroxysteroid dehydrogenase isozymes inhibitor. Measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism with 4-androstenedione increases.(In Vitro):21-deoxycortisol (21dF) and 21-deoxycortisone (21dE) are assayed within the LNCaP cell line to establish that this conversion is catalyzed by the lyase activity of CYP17A1. After the transfection of CYP17A1, 11-Beta-hydroxyandrostenedione (11OHA4)-pathway metabolites increase, 21dF, and 21dE are in fact metabolized to 11-Beta-hydroxyandrostenedione and 11-ketoprogesterone (11KP4) by CYP17A1, respectively .(In Vivo):In 21-hydroxylase deficiency, Cushing's syndrome, and hyperandrogenism of adrenal origin, the plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very high. In congenital 11-hydroxylase deficiency and adrenal insufficiency, the plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very low. Thus, when plasma 4-androstenedione is elevated, it is useful to measure the plasma 11-Beta-hydroxyandrostenedione level in order to determine the adrenal or ovarian origin of the hyperandrogenism .
  • Synonyms
    4-Androsten-11β-ol-3,17-dione; NSC-17102
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Endogenous Metabolite
  • Recptor
    α1-adrenergic receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    382-44-5
  • Formula Weight
    302.4
  • Molecular Formula
    C19H26O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CCC2=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Miura, Y. and K. Yoshinaga, Doxazosin: a newly developed, selective alpha 1-inhibitor in the management of patients with pheochromocytoma. Am Heart J, 1988. 116(6 Pt 2): p. 1785-9.
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