11-Beta-hydroxyandrostenedione
CAS No. 382-44-5
11-Beta-hydroxyandrostenedione ( 4-Androsten-11β-ol-3,17-dione; NSC-17102 )
Catalog No. M26588 CAS No. 382-44-5
11-Beta-hydroxyandrostenedione is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 35 | In Stock |
|
10MG | 58 | In Stock |
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25MG | 115 | In Stock |
|
50MG | 187 | In Stock |
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100MG | 282 | In Stock |
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500MG | 678 | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product Name11-Beta-hydroxyandrostenedione
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NoteResearch use only, not for human use.
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Brief Description11-Beta-hydroxyandrostenedione is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue).
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Description11-Beta-hydroxyandrostenedione is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue), which is a 11β-hydroxysteroid dehydrogenase isozymes inhibitor. Measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism with 4-androstenedione increases.(In Vitro):21-deoxycortisol (21dF) and 21-deoxycortisone (21dE) are assayed within the LNCaP cell line to establish that this conversion is catalyzed by the lyase activity of CYP17A1. After the transfection of CYP17A1, 11-Beta-hydroxyandrostenedione (11OHA4)-pathway metabolites increase, 21dF, and 21dE are in fact metabolized to 11-Beta-hydroxyandrostenedione and 11-ketoprogesterone (11KP4) by CYP17A1, respectively .(In Vivo):In 21-hydroxylase deficiency, Cushing's syndrome, and hyperandrogenism of adrenal origin, the plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very high. In congenital 11-hydroxylase deficiency and adrenal insufficiency, the plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very low. Thus, when plasma 4-androstenedione is elevated, it is useful to measure the plasma 11-Beta-hydroxyandrostenedione level in order to determine the adrenal or ovarian origin of the hyperandrogenism .
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Synonyms4-Androsten-11β-ol-3,17-dione; NSC-17102
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PathwayProteasome/Ubiquitin
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TargetEndogenous Metabolite
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Recptorα1-adrenergic receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number382-44-5
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Formula Weight302.4
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Molecular FormulaC19H26O3
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Purity>98% (HPLC)
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Solubility——
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SMILESC[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CCC2=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Miura, Y. and K. Yoshinaga, Doxazosin: a newly developed, selective alpha 1-inhibitor in the management of patients with pheochromocytoma. Am Heart J, 1988. 116(6 Pt 2): p. 1785-9.
molnova catalog
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