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Home - Products - Angiogenesis - HIF/HIF Prolyl-hydroxylase - HIF2α-IN-2

HIF2α-IN-2

CAS No. 1422955-31-4

HIF2α-IN-2( TCS 7009 | TC S 7009 | TC-S 7009 )

Catalog No. M11779 CAS No. 1422955-31-4

HIF2α-IN-2 is a potent, selective, allosteric inhibitor of HIF-2α PAS-B domain with Kd of 81 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    HIF2α-IN-2
  • Note
    Research use only, not for human use.
  • Brief Description
    HIF2α-IN-2 is a potent, selective, allosteric inhibitor of HIF-2α PAS-B domain with Kd of 81 nM.
  • Description
    HIF2α-IN-2 is a potent, selective, allosteric inhibitor of HIF-2α PAS-B domain with Kd of 81 nM, shows high selectivity and does not affect HIF-1 function; antagonizes HIF-2 heterodimerization and DNA-binding activity in vitro and in cultured cells, reducing HIF-2 target gene expression.
  • In Vitro
    Cell Proliferation Assay Cell Line:HPF cells in hypoxic conditions Concentration:0-100?μM Incubation Time:72 hours Result:Showed greater inhibition of cell proliferation in hypoxic conditions than that in normoxic conditions.
  • In Vivo
    ——
  • Synonyms
    TCS 7009 | TC S 7009 | TC-S 7009
  • Pathway
    Angiogenesis
  • Target
    HIF/HIF Prolyl-hydroxylase
  • Recptor
    HIF/HIF Prolyl-hydroxylase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1422955-31-4
  • Formula Weight
    308.653
  • Molecular Formula
    C12H6ClFN4O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (162.00 mM)
  • SMILES
    O=[N+](C1=C(NC2=CC(F)=CC(Cl)=C2)C=CC3=NON=C31)[O-]
  • Chemical Name
    N-(3-chloro-5-fluorophenyl)-4-nitrobenzo[c][1,2,5]oxadiazol-5-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Scheuermann TH, et al. Nat Chem Biol. 2013 Apr;9(4):271-6.
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