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10-NCP

CAS No. 925681-41-0

10-NCP ( 10-DEBC;NCP )

Catalog No. M16632 CAS No. 925681-41-0

10-NCP (10-DEBC) is a potent neuronal autophagy inducer and increases TDP43 clearance, a reversible and specific inhibitor of Akt activity in vitro.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    10-NCP
  • Note
    Research use only, not for human use.
  • Brief Description
    10-NCP (10-DEBC) is a potent neuronal autophagy inducer and increases TDP43 clearance, a reversible and specific inhibitor of Akt activity in vitro.
  • Description
    10-NCP (10-DEBC) is a potent neuronal autophagy inducer and increases TDP43 clearance, a reversible and specific inhibitor of Akt activity in vitro (complete inhibition at < 5 uM); displays minimal effect on PI3K, PDK1, or SGK1; blocks IGF-I stimulated nuclear translocation of Akt in Rh1 cells and suppressed growth of Rh1, Rh18, and Rh30 cells (IC50=2-5 uM).
  • Synonyms
    10-DEBC;NCP
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Akt
  • Recptor
    Akt
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    925681-41-0
  • Formula Weight
    381.34
  • Molecular Formula
    C20H26Cl2N2O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCN(CC)CCCCN1C2=CC=CC=C2OC3=C1C=C(C=C3)Cl.Cl
  • Chemical Name
    10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Barmada SJ, et al. Nat Chem Biol. 2014 Aug;10(8):677-85.
2. Tsvetkov AS, et al. Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16982-7.
3. Thimmaiah KN, et al. J Biol Chem. 2005 Sep 9;280(36):31924-35.
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