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10-NCP

CAS No. 925681-41-0

10-NCP( 10-DEBC | NCP )

Catalog No. M16632 CAS No. 925681-41-0

10-NCP (10-DEBC) is a potent neuronal autophagy inducer and increases TDP43 clearance, a reversible and specific inhibitor of Akt activity in vitro.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    10-NCP
  • Note
    Research use only, not for human use.
  • Brief Description
    10-NCP (10-DEBC) is a potent neuronal autophagy inducer and increases TDP43 clearance, a reversible and specific inhibitor of Akt activity in vitro.
  • Description
    10-NCP (10-DEBC) is a potent neuronal autophagy inducer and increases TDP43 clearance, a reversible and specific inhibitor of Akt activity in vitro (complete inhibition at < 5 uM); displays minimal effect on PI3K, PDK1, or SGK1; blocks IGF-I stimulated nuclear translocation of Akt in Rh1 cells and suppressed growth of Rh1, Rh18, and Rh30 cells (IC50=2-5 uM).
  • In Vitro
    10-DEBC is found to inhibit the growth of Mtb in whole-cell assay with an IC50 of 12.8 μM, while inhibiting replication of Mtb inside iMACs with an IC50 of 1.5 μM, without host cell toxicity even at the highest concentration of 25 μM.
  • In Vivo
    ——
  • Synonyms
    10-DEBC | NCP
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Akt
  • Recptor
    Akt
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    925681-41-0
  • Formula Weight
    381.341
  • Molecular Formula
    C20H26Cl2N2O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCN(CC)CCCCN1C2=CC=CC=C2OC3=C1C=C(C=C3)Cl.Cl
  • Chemical Name
    10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Barmada SJ, et al. Nat Chem Biol. 2014 Aug;10(8):677-85. 2. Tsvetkov AS, et al. Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16982-7. 3. Thimmaiah KN, et al. J Biol Chem. 2005 Sep 9;280(36):31924-35.
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