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SC-79
CAS No. 305834-79-1
SC-79 ( SC79 )
Catalog No. M13975 CAS No. 305834-79-1
A unique specific Akt activator; binds to the PH domain of Akt and inhibits Akt membrane translocation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 47 | In Stock |
|
| 10MG | 77 | In Stock |
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| 25MG | 129 | In Stock |
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| 50MG | 177 | In Stock |
|
| 100MG | 295 | In Stock |
|
| 200MG | 475 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSC-79
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NoteResearch use only, not for human use.
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Brief DescriptionA unique specific Akt activator; binds to the PH domain of Akt and inhibits Akt membrane translocation.
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DescriptionA unique specific Akt activator; binds to the PH domain of Akt and inhibits Akt membrane translocation, but paradoxically activates Akt in the cytosol; induces the p-Akt (Ser473) expression and significantly increases the expression of Bcl-2 and p-GSK-3β (Ser9), decreases the protein levels of Bax, cytoplasm cytochrome C, and cleaved caspase-3.; augments neuronal survival in mouse model for ischemic strok.
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SynonymsSC79
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetAkt
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RecptorAkt
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number305834-79-1
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Formula Weight364.78
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Molecular FormulaC17H17ClN2O5
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESNC1=C(C(OCC)=O)C(C(C(OCC)=O)C#N)C2=CC(Cl)=CC=C2O1
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Chemical Name4H-1-Benzopyran-4-acetic acid, 2-amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-, ethyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jo H, et al. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10581-6.
2. Zhang D, et al. ACS Chem Neurosci. 2016 Jun 15;7(6):710-8.
3. Hao S, et al. Molecules. 2016 Mar 10;21(3):325.
2. Zhang D, et al. ACS Chem Neurosci. 2016 Jun 15;7(6):710-8.
3. Hao S, et al. Molecules. 2016 Mar 10;21(3):325.
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