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Home - Products - Cytoskeleton/Cell Adhesion Molecules - Akt - SC-79

SC-79

CAS No. 305834-79-1

SC-79 ( SC79 )

Catalog No. M13975 CAS No. 305834-79-1

A unique specific Akt activator; binds to the PH domain of Akt and inhibits Akt membrane translocation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 47 In Stock
10MG 77 In Stock
25MG 129 In Stock
50MG 177 In Stock
100MG 295 In Stock
200MG 475 In Stock
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Biological Information

  • Product Name
    SC-79
  • Note
    Research use only, not for human use.
  • Brief Description
    A unique specific Akt activator; binds to the PH domain of Akt and inhibits Akt membrane translocation.
  • Description
    A unique specific Akt activator; binds to the PH domain of Akt and inhibits Akt membrane translocation, but paradoxically activates Akt in the cytosol; induces the p-Akt (Ser473) expression and significantly increases the expression of Bcl-2 and p-GSK-3β (Ser9), decreases the protein levels of Bax, cytoplasm cytochrome C, and cleaved caspase-3.; augments neuronal survival in mouse model for ischemic strok.
  • Synonyms
    SC79
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Akt
  • Recptor
    Akt
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    305834-79-1
  • Formula Weight
    364.78
  • Molecular Formula
    C17H17ClN2O5
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    NC1=C(C(OCC)=O)C(C(C(OCC)=O)C#N)C2=CC(Cl)=CC=C2O1
  • Chemical Name
    4H-1-Benzopyran-4-acetic acid, 2-amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-, ethyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jo H, et al. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10581-6.
2. Zhang D, et al. ACS Chem Neurosci. 2016 Jun 15;7(6):710-8.
3. Hao S, et al. Molecules. 2016 Mar 10;21(3):325.
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