1-Hydroxyanthraquinone

Research use only, not for human use.

1-Hydroxyanthraquinone is an anthraquinone that has been found in Morinda officinalis and has genotoxic and carcinogenic activities. 1-Hydroxyanthraquinone generates strong DNA repair response.

1-Hydroxyanthraquinone is an anthraquinone that has been found in Morinda officinalis and has genotoxic and carcinogenic activities. 1-Hydroxyanthraquinone generates strong DNA repair response.(In Vitro):1-Hydroxyanthraquinone (5 and 500 μM) increases the percentage of isolated rat hepatocytes undergoing unscheduled DNA synthesis, indicating genotoxic activity.(In Vivo):Dietary administration of 1-Hydroxyanthraquinone (1%) induces formation of cecum and colon adenocarcinomas, as well as hepatocellular carcinomas, in rats.

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1-Hydroxyanthraquinone (HA) generates strong DNA repair response and is carcinogenic in rats. Animal Model:Thirty rats.Dosage:1% HA in diet.Administration:Diet.Result:Associated with decreased weight gain which was particularly marked towards the termination of experiment.One of the 30 rats in group 1 (experimental group) died of pneumonia 243 days after the start of experiment. A second rat died in an unnourished state at day 280, demonstrating a large tumor in the colon.Seven animals of the group died spontaneously or were sacrificed upon becoming mori bund between 335 and 462 days.

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Cell Cycle/DNA Damage

DNA/RNA Synthesis

RORγt

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129-43-1

224.215

C14H8O3

>98% (HPLC)

In Vitro:?DMSO : 16.67 mg/mL (74.35 mM)

Oc1cccc2C(=O)c3ccccc3C(=O)c12

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(-20℃)

With Ice Pack

≥ 2 years