(±)-BI-D ( —— )

Catalog No. M11732 CAS No. 1416258-16-6

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Datasheet

HNMR

HPLC

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Product Name

(±)-BI-D
Note

Research use only, not for human use.
Brief Description

A potent, allosteric HIV integrase inhibitor (Kd=34 nM) that binds the LEDGF/p75 binding site on integrase.
Description

A potent, allosteric HIV integrase inhibitor (Kd=34 nM) that binds the LEDGF/p75 binding site on integrase; inhibits the replication of NL4.3 virus (T124/T125) with EC50 of 51 nM.
Synonyms

——
Pathway

Microbiology/Virology
Target

HIV
Recptor

HIV
Research Area

Infection
Indication

——

CAS Number

1416258-16-6
Formula Weight

405.49
Molecular Formula

C25H27NO4
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CC1=NC2=CC=CC=C2C(=C1C(C(=O)O)OC(C)(C)C)C3=CC4=C(C=C3)OCCC4
Chemical Name

3-Quinolineacetic acid, 4-(3,4-dihydro-2H-1-benzopyran-6-yl)-α-(1,1-dimethylethoxy)-2-methyl-

1. Fader LD, et al. ACS Med Chem Lett. 2014 Apr 16;5(6):711-6.
2. Wang H, et al. Nucleic Acids Res. 2012 Dec;40(22):11518-30.

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