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(S)-Zanubrutinib
CAS No. 1691249-45-2
(S)-Zanubrutinib( S)-Zanubrutinib | BGB3111 | BGB 3111 )
Catalog No. M12579 CAS No. 1691249-45-2
(S)-Zanubrutinib (BGB3111)?is a potent, selective and orally available Btk inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 132 | In Stock |
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| 10MG | 237 | In Stock |
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| 25MG | 537 | In Stock |
|
| 50MG | 767 | In Stock |
|
| 100MG | 1053 | In Stock |
|
| 500MG | 2115 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Name(S)-Zanubrutinib
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NoteResearch use only, not for human use.
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Brief Description(S)-Zanubrutinib (BGB3111)?is a potent, selective and orally available Btk inhibitor.
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Description(S)-Zanubrutinib (BGB3111)?is a potent, selective and orally available Btk inhibitor; shows much more restricted off-target activities against a panel of kinases, including ITK, compared with Ibrutinib; demonstrates nanomolar BTK inhibition activity, inhibits BCR aggregation-triggered BTK autophosphorylation, blocks downstream PLC-γ2 signaling, and potently inhibits cell proliferation in several MCL and DLBCL cell lines; demonstrates better anti-tumor activity than ibrutinib in TMD-8 subcutaneous xenograft model.
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In Vitro——
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In Vivo——
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SynonymsS)-Zanubrutinib | BGB3111 | BGB 3111
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PathwayTyrosine Kinase
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TargetBTK
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RecptorBTK
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1691249-45-2
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Formula Weight471.561
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Molecular FormulaC27H29N5O3
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 56.75 mg/mL 120.35 mM; Ethanol : < 1 mg/mL
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SMILESC=CC(=O)N1CCC(CC1)C2CCNC3=C(C(=NN23)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=O)N
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Chemical Name(7S)-4,5,6,7-Tetrahydro-7-[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Na Li, et al. Abstract 2597: BGB-3111 is a novel and highly selective Bruton's tyrosine kinase (BTK) inhibitor. AACR.
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