(Rac)-Nutlin-3

Research use only, not for human use.

A potent and selective Mdm2 inhibitor with IC50 of 90 nM.

A potent and selective Mdm2 inhibitor with IC50 of 90 nM; binds MDM2 in the p53-binding pocket and activates the p53 pathway in cancer cells, leading to cell cycle arrest, apoptosis, and growth inhibition of human tumor xenografts in nude mice; induces p53 and p21WAF expression in a dose-dependent manner in 22RV1 cells; also can block the MDMX–p53 interaction and induce the p53 pathway in retinoblastoma cells (Weri1) with IC50 of 0.7 uM.

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Nutlin 3 | Nutlin3

Apoptosis

MDM2-p53

MDM2-p53

Cancer

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890090-75-2

581.4896

C30H30Cl2N4O4

>98% (HPLC)

10 mM in DMSO

CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-

(-20℃)

With Ice Pack

≥ 2 years