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Home - Products - Membrane Transporter/Ion Channel - NMDAR - (R)-Serine

(R)-Serine

CAS No. 312-84-5

(R)-Serine( —— )

Catalog No. M21605 CAS No. 312-84-5

(R)-Serine is an endogenous amino acidis a potent co-agonist at the NMDA glutamate receptor.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    (R)-Serine
  • Note
    Research use only, not for human use.
  • Brief Description
    (R)-Serine is an endogenous amino acidis a potent co-agonist at the NMDA glutamate receptor.
  • Description
    (R)-Serine is an endogenous amino acidis a potent co-agonist at the NMDA glutamate receptor.(In Vitro):(R)-Serine is synthesized from L-Ser by serine racemase (SR) and degraded by D-amino acid oxidase (DAAO) and SR. Distribution of D-Ser and NMDAR as determined by chemical measurement and immunohistochemistry supports D-Ser as an endogenous coagonist acting on the glycine modulatory site of the NR1 subunits of the NMDAR.(In Vivo):(R)-Serine (10 g/L; p.o.; throughout 8 weeks) regulates HFD induced weight gain.
  • In Vitro
    (R)-Serine is synthesized from L-Ser by serine racemase (SR) and degraded by D-amino acid oxidase (DAAO) and SR. Distribution of D-Ser and NMDAR as determined by chemical measurement and immunohistochemistry supports D-Ser as an endogenous coagonist acting on the glycine modulatory site of the NR1 subunits of the NMDAR.
  • In Vivo
    (R)-Serine (10 g/L; p.o.; throughout 8 weeks) regulates HFD induced weight gain. Animal Model:Four week old male C57Bl/6 miceDosage:10 g/LAdministration:Oral administration (drinking water supplemented with 10 g/l D-serine); throughout 8 weeksResult:Showed strongly reduced weight gain during the first week of supplementation with paralleled weight gain to HFD fed mice, but no catch up thereafter.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    NMDAR
  • Recptor
    NMDA receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    312-84-5
  • Formula Weight
    105.09
  • Molecular Formula
    C3H7NO3
  • Purity
    >98% (HPLC)
  • Solubility
    H2O:50 mg/mL (475.78 mM)
  • SMILES
    N[C@H](CO)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Dai X et al. D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep. Nat Commun. 2019 May 7;10(1):1986.
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