(R)-Equol
CAS No. 221054-79-1
(R)-Equol ( (+)-Equol )
Catalog No. M26529 CAS No. 221054-79-1
(R)-Equol is an ERα and ERβ agonist with Kis of 27.4 and 15.4 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 32 | In Stock |
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5MG | 51 | In Stock |
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10MG | 87 | In Stock |
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25MG | 146 | In Stock |
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50MG | 214 | In Stock |
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100MG | 322 | In Stock |
|
200MG | 475 | In Stock |
|
500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product Name(R)-Equol
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NoteResearch use only, not for human use.
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Brief Description(R)-Equol is an ERα and ERβ agonist with Kis of 27.4 and 15.4 nM, respectively.
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Description(R)-Equol is an ERα and ERβ agonist with Kis of 27.4 and 15.4 nM, respectively.(In Vitro):(R)-Equol produced a dose-dependent inhibitory effect on the invasive ability of MDA-MB-231 cells, and this inhibitory effect was obvious at the highest test concentration (50 μM).Following 48-h exposure to (R)-Equol, invasion is reduced by 62% (p=0.009, versus untreated cells) with 50 μM (R)-Equol. Matrix metalloproteinase-2 (MMP-2) expression is significantly down-regulated following treatment with 50 μM (R)-Equol (p=0.035) .(In Vivo):In Animals, (R)-Equol has a significantly reduced number of palpable tumors over time when compared with Controls (P=0.002).In addition, the number of palpable tumors formed by each rat in the (R)-Equol fed group was significantly lower than that of rats treated with S-(-)equol (P = 0.008). (R)-Equol-fed animals have 43% fewer tumors than the control group and this difference is highly statistically significant (P=0.004). The number of tumors/tumor-bearing animals is significantly lower in the animals fed (R)-Equol compare with Controls (3.3±0.4 versus 5.5±0.5, P=0.004). At necropsy, the mean (±SEM) tumor weight per animal for (R)-Equol fed rats (5.3±1.1 mg) is significantly reduced (P=0.04) when compared with Controls (9.9±1.4 mg). Feeding the (R)-Equol diet results in significantly increased tumor latency (P=0.003) .
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Synonyms(+)-Equol
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PathwayEndocrinology/Hormones
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TargetEstrogen Receptor/ERR
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RecptormPGES-1
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Research Area——
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Indication——
Chemical Information
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CAS Number221054-79-1
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Formula Weight242.3
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Molecular FormulaC15H14O3
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Purity>98% (HPLC)
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Solubility——
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SMILESOc1ccc(cc1)[C@@H]1COc2cc(O)ccc2C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Guerrero, M.D., Aquino, M., Bruno, I., et al. Synthesis and pharmacological evaluation of a selected library of new potential anti-inflammatory agents bearing the γ-hydroxybutenolide scaffold: a new class of inhibitors of prostanoid production through the selective modulation of microsomal prostaglandin E synthase-1 expression. Journal of Medicinal Chemistry 50, 2176-2184 (2007).
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