Psoriasis

Psoriasis is an immune-mediated, genetic disease manifesting in the skin or joints or both. Psoriasis provides many challenges including high prevalence, chronicity, disfi guration, disability, and associated comorbidity. Psoriasis prevalence is also an important consideration for WHO. Psoriasis is a multifarious disease that is equally prevalent in both sexes, although results from a recent study have shown that on average men have more severe forms of the disease than do women. Chronic plaque psoriasis (psoriasis vulgaris) is the most common form of the disease, and accounts for about 90% of cases.Psoriasis is mainly a dendritic cell and T-cell-mediated disease with complex feedback loops from antigenpresenting cells, neutrophilic granulocytes, keratinocytes, vascular endothelial cells, and the cutaneous nervous system. Cross-talk between the innate and the adaptive immune system mediated by cytokines including TNFα, interferon γ, and interleukin 1 is a major research focus.

References

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2.Wolf-Henning Boehncke, Michael P Sch?n. Lancet 2015; 386: 983–94.