α-Zearalenol

Research use only, not for human use.

α-Zearalenol is one of the major metabolites of Zearalenone. α-Zearalenol has structural analogy to estrogen, thus α-Zearalenol can bind to estrogen receptors (ERs).

α-Zearalenol is one of the major metabolites of Zearalenone. α-Zearalenol has structural analogy to estrogen, thus α-Zearalenol can bind to estrogen receptors (ERs).(In Vitro):α-Zearalenol is resulted able to induce: (i) an increase of the cell viability on MCF-7 cells mainly after 72?h treatment, (ii) a slight decrease of the cell viability on MDA-MB231 cells, and (iii) an increase of cells in S phase of the cell cycle and of ROS only in MCF-7 cells. Moreover, the evaluation of metabolomics profile evidenced that after treatment with α-zol the levels of some metabolites increased in MCF-7 cells whereas decreased slightly in MDA-MB231 cells.

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Endocrinology/Hormones

Estrogen Receptor/ERR

Autophagy; RARγ

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36455-72-8

320.4

C18H24O5

>98% (HPLC)

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C[C@H]1CCC[C@H](O)CCC\C=C\c2cc(O)cc(O)c2C(=O)O1

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(-20℃)

With Ice Pack

≥ 2 years