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sphondin

CAS No. 483-66-9

sphondin( —— )

Catalog No. M20453 CAS No. 483-66-9

Sphondin has anticonvulsant anti-inflammatory and anti-proliferative activities it possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    sphondin
  • Note
    Research use only, not for human use.
  • Brief Description
    Sphondin has anticonvulsant anti-inflammatory and anti-proliferative activities it possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells.
  • Description
    Sphondin has anticonvulsant anti-inflammatory and anti-proliferative activities it possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells.
  • In Vitro
    Pretreatment of A549 cells with Sphondin (10-50 μM) concentration-dependently attenuates IL-1β-induced COX-2 protein expression and PGE2 release.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    COX
  • Recptor
    COX-2|PGE2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    483-66-9
  • Formula Weight
    216.19
  • Molecular Formula
    C12H8O4?
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (115.64 mM)
  • SMILES
    COc1cc2ccc(=O)oc2c2ccoc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yang L L Liang Y C Chang C W et al. Effects of sphondin isolated from Heracleum laciniatum on IL–1β-induced cyclooxygenase-2 expression in human pulmonary epithelial cells[J]. Life Sciences 2002 72(2):199-213.
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