mTOR-IN-1

CAS No. 1207358-59-5

mTOR-IN-1( —— )

Catalog No. M10764 CAS No. 1207358-59-5

A potent and selective mTOR inhibitor with Ki of 1.5 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 88 Get Quote
5MG 147 Get Quote
10MG 205 Get Quote
25MG 356 Get Quote
50MG 530 Get Quote
100MG 759 Get Quote
500MG 1557 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    mTOR-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective mTOR inhibitor with Ki of 1.5 nM.
  • Description
    A potent and selective mTOR inhibitor with Ki of 1.5 nM; >500-fold selectivity over closely related PI3 kinases; exhibits suitable mouse PK and demenstrates active in an NCI-PC3prostate cancer model; orally bioavailable.
  • In Vitro
    ——
  • In Vivo
    mTOR inhibitor-3 (Compound 8h) has high free plasma clearance in both mice (1818 mL/min/kg) and rats (1538 mL/min/kg in rat) . mTOR inhibitor-3 (Compounds 12i) is selected for this study due to its potency, selectivity, and favorable mouse PK profile. Plasma levels of mTOR inhibitor-3 6 h following oral administration in PC3 tumor-bearing mice along with the fold decreases of phosphorylated mTORC1 and -2 substrates relative to time-matched vehicle controls. mTOR inhibitor-3 has moderate terminal elimination half-life (t1/2=1.7 h for mouse(1 mg/kg, iv)). mTOR inhibitor-3 achieves tumor stasis at the highest 200 mg/kg/day dose examined, which appears to also be approaching the limit of tolerability for this molecule.
  • Synonyms
    ——
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    mTOR
  • Recptor
    mTOR
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1207358-59-5
  • Formula Weight
    474.5581
  • Molecular Formula
    C25H30N8O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(CCN(C3)C4=NC=CC=N4)C(=N2)N5CCOCC5C
  • Chemical Name
    Urea, N-ethyl-N'-[4-[5,6,7,8-tetrahydro-4-[(3S)-3-methyl-4-morpholinyl]-7-(2-pyrimidinyl)pyrido[3,4-d]pyrimidin-2-yl]phenyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Koehler MF, et al. J Med Chem. 2012 Dec 27;55(24):10958-71.
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