
mTOR-IN-1
CAS No. 1207358-59-5
mTOR-IN-1( —— )
Catalog No. M10764 CAS No. 1207358-59-5
A potent and selective mTOR inhibitor with Ki of 1.5 nM.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 88 | Get Quote |
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5MG | 147 | Get Quote |
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10MG | 205 | Get Quote |
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25MG | 356 | Get Quote |
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50MG | 530 | Get Quote |
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100MG | 759 | Get Quote |
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500MG | 1557 | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NamemTOR-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective mTOR inhibitor with Ki of 1.5 nM.
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DescriptionA potent and selective mTOR inhibitor with Ki of 1.5 nM; >500-fold selectivity over closely related PI3 kinases; exhibits suitable mouse PK and demenstrates active in an NCI-PC3prostate cancer model; orally bioavailable.
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In Vitro——
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In VivomTOR inhibitor-3 (Compound 8h) has high free plasma clearance in both mice (1818 mL/min/kg) and rats (1538 mL/min/kg in rat) . mTOR inhibitor-3 (Compounds 12i) is selected for this study due to its potency, selectivity, and favorable mouse PK profile. Plasma levels of mTOR inhibitor-3 6 h following oral administration in PC3 tumor-bearing mice along with the fold decreases of phosphorylated mTORC1 and -2 substrates relative to time-matched vehicle controls. mTOR inhibitor-3 has moderate terminal elimination half-life (t1/2=1.7 h for mouse(1 mg/kg, iv)). mTOR inhibitor-3 achieves tumor stasis at the highest 200 mg/kg/day dose examined, which appears to also be approaching the limit of tolerability for this molecule.
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetmTOR
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RecptormTOR
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1207358-59-5
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Formula Weight474.5581
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Molecular FormulaC25H30N8O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(CCN(C3)C4=NC=CC=N4)C(=N2)N5CCOCC5C
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Chemical NameUrea, N-ethyl-N'-[4-[5,6,7,8-tetrahydro-4-[(3S)-3-methyl-4-morpholinyl]-7-(2-pyrimidinyl)pyrido[3,4-d]pyrimidin-2-yl]phenyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Koehler MF, et al. J Med Chem. 2012 Dec 27;55(24):10958-71.
molnova catalog



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